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Thromb Haemost 2003; 90(05): 829-834
DOI: 10.1160/TH03-03-0170
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism

Philip S. Wells
1   Departments of Medicine
2   Epidemiology and Community Medicine
5   Ottawa Health Research Institute, Canada
,
Marc A. Rodger
1   Departments of Medicine
2   Epidemiology and Community Medicine
5   Ottawa Health Research Institute, Canada
,
Melissa A. Forgie
1   Departments of Medicine
2   Epidemiology and Community Medicine
5   Ottawa Health Research Institute, Canada
,
Nicole J. Langlois
5   Ottawa Health Research Institute, Canada
,
Linlea Armstrong
6   Children’s Hospital of Eastern Ontario, Canada
,
Nancy L. Carson
3   Pediatrics, Microbiology and Immunology, University of Ottawa, Canada
4   Biochemistry, Microbiology and Immunology, University of Ottawa, Canada
6   Children’s Hospital of Eastern Ontario, Canada
,
James Jaffey
5   Ottawa Health Research Institute, Canada
› Author AffiliationsGrant support: Heart and Stroke Foundation of Ontario, Grant Number NA4507 Dr. Wells is a Canada Research Chair. Dr. Rodger is a recipient of the Maureen Andrew New Investigator Award (#5078) from the Heart and Stroke Foundation of Canada. N. Langlois is funded through a Premier’s Research Excellence Award, granted to Dr. Wells. Department and institution where work was conducted: Department of Medicine, Ottawa Hospital: General and Civic Campuses, Canada Molecular Genetics Diagnostic Lab, Children’s Hospital of Eastern Ontario, Canada
Further Information

Publication History

Received 20 March 2003

Accepted after revision 03 July 2003

Publication Date:
05 December 2017 (online)

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Summary

The deletion/deletion (D/D) genotype of the angiotensin converting enzyme (ACE) has been purported to be a risk for postoperative thrombosis. This D/D genotype has not been evaluated as a risk factor for idiopathic venous thromboembolism (VTE).

The primary objective of the present study was to determine whether the D/D genotype of ACE is independently associated with the occurrence of idiopathic venous thromboembolic disease.

We prospectively enrolled consecutive patients with at least one objectively confirmed idiopathic VTE. Friends of cases were recruited as controls and matched to cases by sex, ethnicity, and age. Patients were tested for the ACE I/D polymorphism in addition to factor V Leiden, prothrombin G20210A, and factor VIII levels.

Three hundred cases and 300 controls were enrolled; 97% were Caucasian. There were 148 females and 152 males in each group with a mean age of 56.21 years (SD=15.33). The ACE D/D genotype was present in 25.3% of cases and 32.4% of controls for an adjusted odds ratio of 0.66 (95% CI = 0.433 to 0.997). We can conclude that the ACE D/D genotype is protective against idiopathic venous thromboembolism.

Keywords

ACE - angiotensin converting enzyme - venous thromboembolism - deep vein thrombosis - pulmonary embolism
 

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