Regulatory roles of androgens in cutaneous wound healing

Stephen C. Gilliver; Fred Wu; Gillian S. Ashcroft

doi:10.1160/TH03-05-0302

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 90(06): 978-985
DOI: 10.1160/TH03-05-0302

Theme Issue Article

Schattauer GmbH

Regulatory roles of androgens in cutaneous wound healing

Stephen C. Gilliver

¹Division of Immunology, Microbiology, Development and Repair, School of Biological Sciences, University of Manchester, UK

,

Fred Wu

¹Division of Immunology, Microbiology, Development and Repair, School of Biological Sciences, University of Manchester, UK

,

Gillian S. Ashcroft

¹Division of Immunology, Microbiology, Development and Repair, School of Biological Sciences, University of Manchester, UK

› Author Affiliations

Abstract

Summary

Although the effects of androgens on wound healing are poorly characterised, the androgen receptor is expressed by inflammatory cells, keratinocytes and fibroblasts during wound healing, suggesting that androgens may regulate inflammatory and/or repair processes. In fact, it appears that endogenous testosterone inhibits wound healing and promotes inflammation since castration of male mice or systemic treatment with the androgen receptor antagonist flutamide accelerates cutaneous wound healing and reduces the inflammatory response. The aim of this review is to summarise our current knowledge about the regulation of tissue repair processes by androgens.

Keywords

Testosterone - androgen receptor - wound - castration - inflammation

Full Text

References

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