Thrombophilia and pregnancy complications

Benjamin Brenner; Eric F. Grabowski; Margaretta Hellgren; Gili Kenet; Patricia Massicotte; Marilyn Manco-Johnson; Prasad Mathew; Wolfgang Muntean; Nicole Schlegel; Ulrike Nowak-Göttl

doi:10.1160/TH04-02-0096

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(04): 678-681
DOI: 10.1160/TH04-02-0096

Theme Issue Article

Schattauer GmbH

Thrombophilia and pregnancy complications

Benjamin Brenner

¹Thrombosis and Hemostasis Unit, Rambam Medical Center, Haifa, Israel

,

Eric F. Grabowski

²Cardiovascular Thrombosis Laboratory, Massachusetts General Hospital, Boston, USA

,

Margaretta Hellgren

³Department of Obstetrics and Gynecology, Goteborg University and Sahlgrenska University Hospital, Sweden

,

Gili Kenet

⁴The Pediatric Coagulation Service, Sheba Medical Center, Tel Hashomer, Israel

,

Patricia Massicotte

⁵Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Canada

,

Marilyn Manco-Johnson

⁶Mountain States Hemophilia Center, Aurora, Colorado, USA

,

Prasad Mathew

⁷Department of Pediatrics, University of New Mexico Health Science Center, Albuquerque, USA

,

Wolfgang Muntean

⁸Department of Pediatrics, University of Graz, Graz, Austria

,

Nicole Schlegel

⁹Service d’Hematologie Biologique, Hopital Robert Debre, Paris, France

,

Ulrike Nowak-Göttl

¹⁰Pediatric Hematology/Oncology, University Children’s Hospital, Munster, Germany

› Author Affiliations

Abstract

Summary

The implications of currently available data on the association of gestational vascular complications with thrombophilia are presented in this consensus report. Screening is recommended for women with the following previous complications: fetal loss including three or more first trimester loss, two or more second trimester loss, or any stillbirth; early, severe or recurrent preeclampsia and severe intrauterine growth restriction. Maternal antithrombotic therapy is currently evaluated in women with thrombophilia and previous complications.

On behalf of the Scientific Subcommittee on Perinatal and Pediatric Hemostasis and Working Group on Women’s health Issues and Standardization Committee of the International Society of Thrombosis and Hemostasis.

Keywords

Thrombophilia - pregnancy - antithrombotic therapy - fetal loss

Full Text

References

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