Role of P-selectin and PSGL-1 in coagulation and thrombosis

Erik R.Vandendries; Barbara C. Furie; Bruce Furie

doi:10.1160/TH04-05-0306

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(03): 459-466
DOI: 10.1160/TH04-05-0306

Theme Issue Article

Schattauer GmbH

Role of P-selectin and PSGL-1 in coagulation and thrombosis

Erik R.Vandendries

¹Center for Hemostasis,Thrombosis, and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

,

Barbara C. Furie

¹Center for Hemostasis,Thrombosis, and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

,

Bruce Furie

¹Center for Hemostasis,Thrombosis, and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

› Author Affiliations

Abstract

Summary

P-selectin and PSGL-1 are cell adhesion molecules, regulating the initial interactions between leukocytes and the blood vessel wall as well as between activated platelets and leukocytes. P-selectin is expressed on activated endothelial cells and platelets, while its major ligand PSGL-1 is expressed on leukocytes. Multiple studies have shown that these adhesion molecules are required for the normal recruitment of leukocytes during an inflammatory reaction. More recently, these adhesion molecules have been implicated in recruitment of leukocytes and leukocyte microparticles to thrombi. The P-selectinand PSGL-1-dependent delivery of circulating microparticles to thrombi appears to be important for normal tissue factor accumulation and fibrin generation in thrombi.

Keywords

Thrombosis - blood coagulation - P-selectin - PSGL-1 - leukocyte - microparticles - tissue factor - fibrin

Full Text

References

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