Thrombosis and Haemostasis, Table of Contents Thromb Haemost 2005; 93(01): 23-26DOI: 10.1160/TH04-08-0540 Rapid and Short Communication Schattauer GmbH Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1 Dominic J. Harrington 1 The Centre for Haemostasis and Thrombosis, St. Thomas’ Hospital, London, United Kingdom , Sarah Underwood 2 Department of Haematology, Bristol Royal Infirmary, Bristol, United Kingdom , Colin Morse 2 Department of Haematology, Bristol Royal Infirmary, Bristol, United Kingdom , Martin J. Shearer 1 The Centre for Haemostasis and Thrombosis, St. Thomas’ Hospital, London, United Kingdom , Edward G. D. Tuddenham 3 Haemostasis and Thrombosis, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom , Andrew D. Mumford 2 Department of Haematology, Bristol Royal Infirmary, Bristol, United Kingdom › Author Affiliations Recommend Article Abstract Full Text PDF Download Keywords KeywordsWarfarin resistance - vitamin K - vitamin K epoxide reductase - pharmacogenetics - coagulation factor References References 1 Hirsh J, Fuster V, Ansell J. et al American Heart Association/ American College of Cardiology Foundation guide to warfarin therapy. Circulation 2003; 107: 1692-711. 2 James AH, Britt RP, Raskino CL. et al Factors affecting the maintenance dose of warfarin. J Clin Pathol 1992; 45: 704-6. 3 Palareti G, Leali N, Coccheri S. et al Bleeding complications of oral anticoagulant treatment: an inception- cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet 1996; 348: 423-8. 4 Gage BF, Eby C, Milligan PE. et al Use of pharmacogenetics and clinical factors to predict the maintenance dose of warfarin. Thromb Haemost 2004; 91: 87-94. 5 Suttie JW. The biochemical basis of warfarin therapy. Adv Exp Med Biol 1987; 214: 3-16. 6 Presnell SR, Stafford DW. The vitamin K-dependent carboxylase. Thromb Haemost 2002; 87: 937-46. 7 Rost S, Fregin A, Ivaskevicius V. et al Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004; 427: 537-41. 8 Li T, Chang CY, Jin DY. et al Identification of the gene for vitamin K epoxide reductase. Nature 2004; 427: 541-4. 9 D’Andrea G, D’Ambrosio RL, Di Perna P. et al A polymorphism in VKORC1 gene is associated with an inter-individual variability in the dose-anticoagulant effect of warfarin. Blood 2004 Sep 9 [Epub ahead of print]. 10 Shearer MJ. Assay of coumarin antagonists of vitamin K in blood by high-performance liquid chromatography. Methods Enzymol 1986; 123: 223-34. 11 Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods Enzymol 1997; 282: 408-21. 12 Belle M, Brebant R, Guinet R. et al Production of a new monoclonal antibody specific to human des-gamma-carboxyprothrombin in the presence of calcium ions. Application to the development of a sensitive ELISA-test. J Immunoassay 1995; 16: 213-29. 13 Kamali F, Edwards C, Butler TJ. et al The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation. Thromb Haemost 2000; 84: 39-42. 14 Diab F, Feffer S. Hereditary warfarin resistance. South Med J 1994; 87: 407-9. 15 O'Reilly RA, Aggeler PM, Hoag MS. et al Hereditary transmission of exceptional resistance to coumarin anticoagulant drugs. the first reported kindred. N Engl J Med 1964; 271: 809-15. 16 O'Reilly RA. Vitamin K in hereditary resistance to oral anticoagulant drugs. Am J Physiol 1971; 221: 1327-30. 17 Alving BM, Strickler MP, Knight RD. et al Hereditary warfarin resistance. Investigation of a rare phenomenon. Arch Intern Med 1985; 145: 499-501. 18 Warrier I, Brennan CA, Lusher JM. Familial warfarin resistance in a black child. Am J Pediatr Hematol Oncol 1986; 8: 346-7. 19 Hallak HO, Wedlund PJ, Modi MW. et al High clearance of (S)-warfarin in a warfarin-resistant subject. Br J Clin Pharmacol 1993; 35: 327-30. 20 Bentley DP, Backhouse G, Hutchings A. et al Investigation of patients with abnormal response to warfarin. Br J Clin Pharmacol 1986; 22: 37-41. 21 Kempin SJ. Warfarin resistance caused by broccoli. N Engl J Med 1983; 308: 1229-30. 22 Goodstadt L, Ponting CP. Vitamin K epoxide reductase: homology, active site and catalytic site. Trends Biochem Sci 2004; 29: 289-9.
