Comment on: “The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia” by Spiel et al.

Thromb Haemost 2006; 95(06): 1048-1049
DOI: 10.1160/TH06-03-0142

Letters to the Editor

Schattauer GmbH

Evangelos Messaris

¹1st Department of Propedeutic Surgery, Laboratory of Medical Research, Athens Medical School, University of Athens, Greece

,

Nikolaos Memos

¹1st Department of Propedeutic Surgery, Laboratory of Medical Research, Athens Medical School, University of Athens, Greece

,

Frantzeska Frantzeskaki

²Intensive Care Unit, Hippokration General Hospital; Athens, Greece

,

Venetia Economou

¹1st Department of Propedeutic Surgery, Laboratory of Medical Research, Athens Medical School, University of Athens, Greece

,

Alex Betrosian

²Intensive Care Unit, Hippokration General Hospital; Athens, Greece

References
1 Spiel AO, Firbas C, Mayr FB. et al. The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia. Thromb Haemost 2005; 94: 1148-55.
2 Memos N, Adamidis V, Frantzeskaki F. et al. Protein C zymogen infusion reduces inflammation and apoptotic proteins expression in septic rat lung [Abstr]. 18th annual congress, European Society of Intensive Care Medicine S72.
3 Betrosian A, Balla M, Kofinas G. et al. ProteinC in the treatment of coagulopathy in meningococcal sepsis. Crit Care Med 1999; 27: 2849-50.
4 White B, Livingstone W, Murphy C. et al. An openlabel study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura ful-minans-associated meningococcemia. Blood 2000; 96: 3719-24.
5 Rintala E, Kauppila M, Seppala OP. et al. ProteinC substitution in sepsis-associated purpura fulminans. Crit Care Med 2000; 28: 2373-8.