Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women

Alenka Mavri; Delphine Bastelica; Marjorie Poggi; Pierre Morange; Franck Peiretti; Monique Verdier; Irène Juhan-Vague; Marie-Christine Alessi

doi:10.1160/TH06-06-0314

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(01): 62-66
DOI: 10.1160/TH06-06-0314

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women

Alenka Mavri

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

²University Medical Centre, Department of Vascular Disease, Ljubljana, Slovenia

,

Delphine Bastelica

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Marjorie Poggi

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Pierre Morange

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Franck Peiretti

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Monique Verdier

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Irène Juhan-Vague

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

,

Marie-Christine Alessi

¹Inserm UMR 626 and Université de la Méditerranée, Marseille, France

› Author Affiliations

Abstract

Summary

The tumor necrosis factor (TNF) pathway may be implicated in etiopathogenesis of PAI-1 overexpression during obesity. The aim of this study was to investigate the influence of polymorphismA36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. Genotypic and allele frequencies did not significantly differ between obese and lean subjects. TNFRSF1A genotypes were significantly associated with sTNFR1 plasma levels in obese women only (p<0.01); TNFRSF1A +36G/G obese carriers exhibited higher sTNFR1 and PAI-1 levels than A carriers (p<0.01 and p<0.05, respectively). In obese women, the presence of the MetS significantly potentiated the elevation of sTNFR1 and PAI-1 levels observed in the TNFRSF1A+36G/G carriers. Our results suggest that association between TNFRSF1A +36G/G genotype and the MetS renders obese women more prone to activation of the TNF pathway reflected by high circulating sTNFR1 and PAI-1 levels.

Keywords

Obesity - metabolic syndrome - inflammation - TNFR1 - PAI-1

Full Text

References

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