Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: Are these results really discordant?

Thromb Haemost 2007; 97(04): 675-676
DOI: 10.1160/TH06-11-0664

Letters to the Editor

Schattauer GmbH

Yesim Dargaud

¹Laboratoire d’Hémostase, Hopital Edouard Herriot, Lyon, France

²Unite d’Hemostase Clinique, Hopital Edouard Herriot, Lyon, France

,

Jean Claude Bordet

¹Laboratoire d’Hémostase, Hopital Edouard Herriot, Lyon, France

,

Stéphanie Francillon

¹Laboratoire d’Hémostase, Hopital Edouard Herriot, Lyon, France

,

Claude Négrier

¹Laboratoire d’Hémostase, Hopital Edouard Herriot, Lyon, France

²Unite d’Hemostase Clinique, Hopital Edouard Herriot, Lyon, France

References
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2 Sorensen B, Ingerslev J. Whole blood clot formation phenotypes in haemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa. J Thromb Haemost 2004; 2: 102-110.
3 Hemker HC, Giesen P, Al Dieri R. et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15.
4 Dargaud Y, Beguin S, Lienhart A. et al. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Thromb Haemost 2005; 93: 475-480.
5 Beltran-Miranda CP, Khan A, Jaloma-Cruz AR. et al. Thrombin generation and phenotypic correlation in haemophilia A. Haemophilia 2005; 11: 326-334.
6 Dargaud Y, Luddington R, Baglin T. Platelet dependent thrombography: a method for diagnostic laboratories. B J Haematol 2006; 134: 323-3.