Influence of low-density lipoprotein (LDL) receptor-related protein and ABO blood group genotypes on factor XI levels

Giovanna Marchetti; Barbara Lunghi; Gianni Mazzoni; Michela Cini; Cristina Legnani; Francesco Bernardi

doi:10.1160/TH07-12-0749

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2008; 99(04): 789-790
DOI: 10.1160/TH07-12-0749

Letters to the Editor

Schattauer GmbH

Influence of low-density lipoprotein (LDL) receptor-related protein and ABO blood group genotypes on factor XI levels

Giovanna Marchetti

¹Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy

,

Barbara Lunghi

¹Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy

,

Gianni Mazzoni

¹Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy

,

Michela Cini

²Department of Angiology, Unità Ricerca Clinica sulla Trombofilia "Marino Golinelli", University Hospital S.Orsola-Malpighi, Bologna, Italy

,

Cristina Legnani

²Department of Angiology, Unità Ricerca Clinica sulla Trombofilia "Marino Golinelli", University Hospital S.Orsola-Malpighi, Bologna, Italy

,

Francesco Bernardi

¹Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy

References
1 Meijers JCM, Tekelenburg WLH, Bouma BN. et al. High levels of factor XI as a risk factor for venous thrombosis. N Engl J Med 2000; 342: 696-701.
2 Yang DT, Flanders MM, Kim H. et al. Elevated factor XI activity levels are associated with an increased odds ratio for cerebrovascular events. Am J Clin Pathol 2006; 126: 411-415.
3 Seligsohn U. Factor XI in haemostasis and thrombosis: past, present and future. Thromb Haemost 2007; 98: 84-89.
4 Gerdes VE, Kraaijenhagen RA, Vogels EW. et al. Factor XI gene analysis in thrombophilia and factor XI deficiency. J Thromb Haemost 2004; 2: 1015-1017.
5 Mitchell MJ, Dai L, Clarke JB. et al. Characterisation of five factor XI mutations. Thromb Haemost 2007; 97: 884-889.
6 Hill M, McLeod F, Franks H. et al. Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion. Br J Haematol 2005; 129: 825-829.
7 Knauer DJ, Majumdar D, Fong PC. et al. Serpin regulation of factor XIa. The novel observation that protease nexin 1 in the presence of heparin is a more potent inhibitor of factor XIa than C1 inhibitor. J Biol Chem 2000; 275: 37340-37346.
8 Morange PE, Tregouet DA, Frere C. et al. Biological and genetic factors influencing plasma factor VIII levels in a healthy family population: results from the Stanislas cohort. Br J Haematol 2005; 128: 91-99.
9 Tirado I, Mateo J, Soria JM. et al. The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism. Thromb Haemost 2005; 93: 468-474.
10 Marchetti G, Lunghi B, Legnani C. et al. Contribution of low density lipoprotein receptor-related protein genotypes to coagulation factor VIII levels in thrombotic women. Haematol 2006; 91: 1261-1263.
11 Glaser C, Schulz S, Handschug K. et al. Genetic and functional characteristics of the human in vivo LRP1/A2MR receptor suggested as a risk marker for Alzheimer’s disease and other complex (degenerative) diseases. Neurosci Res 2004; 50: 85-101.