Omics meets hypothesis-driven research

Curzio Rüegg; Jean-Daniel Tissot; Pierre Farmer; Agnese Mariotti

doi:10.1160/TH08-06-0348

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 100(05): 738-746
DOI: 10.1160/TH08-06-0348

Editorial Focus

Schattauer GmbH

Omics meets hypothesis-driven research

Partnership for innovative discoveries in vascular biology and angiogenesis

Authors

Curzio Rüegg

¹Division of Experimental Oncology, Centre Pluridisciplinaire d’Oncologie, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland

²National Centre for Competence in Research (NCCR) Molecular Oncology, Epalinges, Switzerland
Jean-Daniel Tissot

³Service RégionalVaudois de Transfusion Sanguine, Lausanne, Switzerland
Pierre Farmer

²National Centre for Competence in Research (NCCR) Molecular Oncology, Epalinges, Switzerland

⁴Swiss Institute of Bioinformatics, Bioinformatics Core Facility, Quartier Sorge, Bâtiment Génopode, Lausanne, Switzerland
Agnese Mariotti

¹Division of Experimental Oncology, Centre Pluridisciplinaire d’Oncologie, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland

Abstract

Summary

The emergence of omics technologies allowing the global analysis of a given biological or molecular system, rather than the study of its individual components,has revolutionized biomedical research, including cardiovascular medicine research in the past decade. These developments raised the prospect that classical,hypothesis-driven,single gene-based approaches may soon become obsolete. The experience accumulated so far, however, indicates that omic technologies only represent tools similar to those classically used by scientists in the past and nowadays, to make hypothesis and build models, with the main difference that they generate large amounts of unbiased information.Thus,omics and classical hypothesis-driven research are rather complementary approaches with the potential to effectively synergize to boost research in many fields, including cardiovascular medicine. In this article we discuss some general aspects of omics approaches, and review contributions in three areas of vascular biology, thrombosis and haemostasis, atherosclerosis and angiogenesis, in which omics approaches have already been applied (vasculomics).

Keywords

Atherosclerosis - endothelial cells - gene expression - proteomics - cancer

Full Text

References

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