Fibrinogen gamma gene 3’-end polymorphisms and risk of venous thromboembolism in the African-American and Caucasian population

Shirley Uitte de Willige; Meridith E. Pyle; Hans L. Vos; Marieke C. H. de Visser; Cathy Lally; Nicole F. Dowling; W. Craig Hooper; Rogier M. Bertina; Harland Austin

doi:10.1160/TH08-12-0813

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 101(06): 1078-1084
DOI: 10.1160/TH08-12-0813

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Fibrinogen gamma gene 3’-end polymorphisms and risk of venous thromboembolism in the African-American and Caucasian population

Shirley Uitte de Willige

¹Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands

,

Meridith E. Pyle

²Division of Hereditary Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

,

Hans L. Vos

¹Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands

,

Marieke C. H. de Visser

¹Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands

,

Cathy Lally

³Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

,

Nicole F. Dowling

²Division of Hereditary Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

,

W. Craig Hooper

²Division of Hereditary Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

,

Rogier M. Bertina

¹Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands

,

Harland Austin

³Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA

› Author Affiliations

Abstract

Summary

Genetic determinants of venous thromboembolism (VTE) in the African-American population are poorly characterised. It was recently shown that fibrinogen gamma gene (FGG) polymorphisms 10034C>T and 9340T>C influence VTE risk in the Caucasian population. In the African-American population these polymorphisms are common, with allele frequencies above 25%. Here we evaluated whether these and other FGG 3’-end polymorphisms were associated with VTE risk in the African-American population and aimed to replicate the association in the Caucasian population. We examined 557 Caucasian patients and 678 Caucasian controls, and 537 African-American patients and 586 African-American controls from the ‘Genetic Attributes and Thrombosis Epidemiology’ (GATE) study. In the African-American population, 10034C>T and 9340T>C marginally influenced VTE-risk, with a 20% increase in risk for 10034TT carriers and a 20% reduction in risk for 9340CC carriers. In the Caucasian population, 10034TT was associated with a 1.7-fold increase in risk, which increased to 2.1-fold for idiopathic VTE patients. 9340CC significantly reduced VTE risk approximately two-fold. In conclusion, both FGG polymorphisms 10034C>T and 9340T>C influence VTE-risk, with the strongest effects observed in the Caucasian population, confirming previous data on these polymorphisms in this population.

Keywords

African-Americans - fibrinogen gamma - polymorphisms - risk - venous thromboembolism

Full Text

References

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