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Thromb Haemost 2009; 101(06): 991-992
DOI: 10.1160/TH09-04-0275
Editorial Focus
Schattauer GmbH

Prolactin as a modulator of platelet function and thrombosis: The end of the story, or a new beginning?

Nana-Maria Heida
1   Department of Cardiology and Pulmonology, University of Goettingen, Goettingen, Germany
,
Katrin Schäfer
1   Department of Cardiology and Pulmonology, University of Goettingen, Goettingen, Germany
,
Stavros Konstantinides
1   Department of Cardiology and Pulmonology, University of Goettingen, Goettingen, Germany
› Author Affiliations
Further Information

Publication History

Received: 29 April 2009

Accepted: 29 April 2009

Publication Date:
24 November 2017 (online)

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  • References

  • 1 Reuwer AQ, Nieuwland R, Frenandez I. et al. Prolactin does not affect human platelet aggregation or secretion. Thromb Haemost 2009; 101: 1119-1127.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Raaz D, Wallaschofski H, Stumpf C. et al. Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression. Horm Metab Res 2006; 38: 767-772.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Wallaschofski H, Lohmann T, Hild E. et al. Enhanced platelet activation by prolactin in patients with ischemic stroke. Thromb Haemost 2006; 96: 38-44.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Wallaschofski H, Kobsar A, Sokolova O. et al. Co-activation of platelets by prolactin or leptin--patho-physiological findings and clinical implications. Horm Metab Res 2004; 36: 1-6.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Wallaschofski H, Kobsar A, Koksch M. et al. Prolactin receptor signaling during platelet activation. Horm Metab Res 2003; 35: 228-235.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
    CrossrefPubMedGoogle Scholar
  • 7 Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-1234.
    CrossrefPubMedGoogle Scholar
  • 8 Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 2008; 28: 403-412.
    CrossrefPubMedGoogle Scholar
  • 9 Bodary PF. Links between adipose tissue and thrombosis in the mouse. Arterioscler Thromb Vasc Biol 2007; 27: 2284-2291.
    CrossrefPubMedGoogle Scholar
  • 10 Bodary PF, Westrick RJ, Wickenheiser KJ. et al. Effect of leptin on arterial thrombosis following vascular injury in mice. Jama-Journal of the American Medical Association 2002; 287: 1706-1709.
    PubMedGoogle Scholar
  • 11 Konstantinides S, Schäfer K, Koschnick S. et al. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108: 1533-40.
    CrossrefPubMedGoogle Scholar
  • 12 Konstantinides S, Schäfer K, Neels JG. et al. Inhibition of endogenous leptin protects mice from arterial and venous thrombosis. Arterioscler Thromb Vasc Biol 2004; 24: 2196-2201.
    CrossrefPubMedGoogle Scholar
  • 13 Dellas C, Schäfer K, Rohm IK. et al. Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2. Thromb Haemost 2007; 98: 1063-1071.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 14 Elbatarny HS, Maurice DH. Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex. Am J Physiol Endocrinol Metab 2005; 289: E695-E702.
    CrossrefPubMedGoogle Scholar
  • 15 Corsonello A, Malara A, De Domenico D. et al. Identifying pathways involved in leptin-dependent aggregation of human platelets. Int J Obes Relat Metab Disord 2004; 28: 979-984.
    CrossrefPubMedGoogle Scholar
  • 16 Dellas C, Schäfer K, Rohm I. et al. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost 2008; 100: 1123-1129.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Kato H, Kashiwagi H, Shiraga M. et al. Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vasc Biol 2006; 26: 224-22430.
    CrossrefPubMedGoogle Scholar
  • 18 Zabeau L, Lavens D, Peelman F. et al. The ins and outs of leptin receptor activation. FEBS Lett 2003; 546: 45-50.
    CrossrefPubMedGoogle Scholar
  • 19 Wallaschofski H, Kobsar A, Sokolova O. et al. Differences in platelet activation by prolactin and leptin. Horm Metab Res 2004; 36: 453-457.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Atmaca A, Gurlek A, Dagdelen S. et al. Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. Exp Clin Endocrinol Diabetes 2006; 114: 188-191.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 21 Gainsford T, Willson TA, Metcalf D. et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-14568.
    CrossrefPubMedGoogle Scholar
  • 22 Nakata M, Yada T, Soejima N. et al. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-429.
    CrossrefPubMedGoogle Scholar
  • 23 Giandomenico G, Dellas C, Czekay RP. et al. The leptin receptor system of human platelets. J Thromb Haemost 2005; 3: 1042-1049.
    CrossrefPubMedGoogle Scholar
  • 24 Kamikubo Y, Dellas C, Loskutoff DJ. et al. Contribution of leptin receptor N-linked glycans to leptin binding. Biochem J 2008; 410: 595-604.
    CrossrefPubMedGoogle Scholar
  • 25 Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004; 59: 305-331.
    CrossrefPubMedGoogle Scholar
  • 26 Rafail S, Ritis K, Schäfer K. et al. Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement. Thromb Res 2008; 122: 366-375.
    CrossrefPubMedGoogle Scholar
  • 27 Napoleone E, DI SA, Amore C. et al. Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk?. J Thromb Haemost 2007; 5: 1462-1468.
    CrossrefPubMedGoogle Scholar