Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis

Aurélie S. Leroyer; Francine Anfosso; Romaric Lacroix; Florence Sabatier; Stéphanie Simoncini; Sébastien M. Njock; Noémie Jourde; Philippe Brunet; Laurence Camoin-Jau; José Sampol; Françoise Dignat-George

doi:10.1160/TH10-02-0111

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(03): 456-463
DOI: 10.1160/TH10-02-0111

Theme Issue Article

Schattauer GmbH

Endothelial-derived microparticles: Biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis

Aurélie S. Leroyer

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

,

Francine Anfosso

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

,

Romaric Lacroix

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

²Laboratoire d’Hématologie, Hôpital de La Conception, Assistance publique – hôpitaux de Marseille, Marseille, France

,

Florence Sabatier

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

³Laboratoire de Culture et Thérapie Cellulaire, INSERM CIC-BT 510, Hôpital de la Conception, Assistance publique –hôpitaux de Marseille, Marseille, France

,

Stéphanie Simoncini

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

,

Sébastien M. Njock

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

,

Noémie Jourde

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

⁴Centre de néphrologie et de transplantation rénale, hôpital de la Conception, Assistance publique – Hôpitaux de Marseille, Marseille, France

,

Philippe Brunet

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

⁴Centre de néphrologie et de transplantation rénale, hôpital de la Conception, Assistance publique – Hôpitaux de Marseille, Marseille, France

,

Laurence Camoin-Jau

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

²Laboratoire d’Hématologie, Hôpital de La Conception, Assistance publique – hôpitaux de Marseille, Marseille, France

,

José Sampol

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

,

Françoise Dignat-George

¹Laboratoire de Physiopathologie de l‘Endothélium - UMR_S 608 INSERM, Université de la Mediterranée, Marseille, France

²Laboratoire d’Hématologie, Hôpital de La Conception, Assistance publique – hôpitaux de Marseille, Marseille, France

› Author Affiliations

Abstract

Summary

Endothelial microparticles (EMP) are complex vesicular structures that can be shed by activated or apoptotic endothelial cells. EMP are composed of a phospholipid bilayer that exposes transmembrane proteins and receptors and encloses cytosolic components such as enzymes, transcription factors and mRNA derived from their parent cells. Thus, EMP behave as biological conveyors playing a key role in the tuning of vascular homeostasis. This review focuses on the multifaceted roles of EMP, notably in coagulation, inflammation and angiogenesis and also on the mechanisms that trigger their formation. In this context, EMP could compromise vascular homeostasis and then represent key players in the pathogenesis of several inflammatory and thrombotic diseases. Consequently, elucidating their role and their mechanisms of formation will bring new insights into the understanding of endothelial-associated diseases. Moreover, in the future, it can open novel therapeutic perspectives based on the inhibition of EMP release.

Keywords

Microparticles - endothelium - coagulation - inflammation - thrombosis - vascular homeostasis - vesiculation

Full Text

References

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