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Thromb Haemost 2011; 105(01): 31-39
DOI: 10.1160/TH10-06-0406
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Predictive factors for concurrent deep-vein thrombosis and symptomatic venous thromboembolic recurrence in case of superficial venous thrombosis

The OPTIMEV study
Jean-Philippe Galanaud
1   Vascular medicine unit, Department of internal medicine, University Hospital, Montpellier, France
2   Research Unit EA2992, Montpellier 1 University, Montpellier, France
,
Celine Genty
3   Techniques de l’Ingénierie Médicale et de la Complexité (TIMC), Unité Mixte de Recherche 5525, Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier, Grenoble, France
4   Clinical Investigation Center, University Hospital, Grenoble, France
,
Marie-Antoinette Sevestre
3   Techniques de l’Ingénierie Médicale et de la Complexité (TIMC), Unité Mixte de Recherche 5525, Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier, Grenoble, France
4   Clinical Investigation Center, University Hospital, Grenoble, France
5   Vascular medicine Unit, Amiens University Hospital, Amiens, France
,
Dominique Brisot
1   Vascular medicine unit, Department of internal medicine, University Hospital, Montpellier, France
6   Vascular medicine physician, Clapiers, France
,
Michel Lausecker
7   Vascular medicine physician, Selestat, France
,
Jean-Luc Gillet
8   Vascular medicine physician, Bourgoin-Jallieu, France
,
Carole Rolland
3   Techniques de l’Ingénierie Médicale et de la Complexité (TIMC), Unité Mixte de Recherche 5525, Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier, Grenoble, France
4   Clinical Investigation Center, University Hospital, Grenoble, France
,
Marc Righini
9   Division of Angiology and Haemostasis, Geneva University Hospital, Geneva, Switzerland
,
Georges Leftheriotis
10   Vascular Medicine Unit, University Hospital, Angers, France
,
Jean-Luc Bosson
3   Techniques de l’Ingénierie Médicale et de la Complexité (TIMC), Unité Mixte de Recherche 5525, Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier, Grenoble, France
4   Clinical Investigation Center, University Hospital, Grenoble, France
,
Isabelle Quere
1   Vascular medicine unit, Department of internal medicine, University Hospital, Montpellier, France
2   Research Unit EA2992, Montpellier 1 University, Montpellier, France
,
the OPTIMEV SFMV investigators › Author Affiliations Financial support: The study was funded by a grant from the Hospital Clinical Research Program of the French Ministry of Health and a grant from Sanofi-Aventis. This study was supported by the French Society of Vascular Medicine (SFMV). All investigators are members of the SFMV.
Further Information

Publication History

Received: 25 June 2010

Accepted after minor revision: 10 September 2010

Publication Date:
22 November 2017 (online)

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Summary

Superficial venous thrombosis (SVT) prognosis is debated and its management is highly variable. It was the objective of this study to assess predictive risk factors for concurrent deep-vein thrombosis (DVT) at presentation and for three-month adverse outcome. Using data from the prospective multicentre OPTIMEV study, we analysed SVT predictive factors associated with concurrent DVT and three-month adverse outcome. Out of 788 SVT included, 227 (28.8%) exhibited a concurrent DVT at presentation. Age >75years (odds ratio [OR]=2.9 [1.5–5.9]), active cancer (OR=2.6 [1.3–5.2]), inpatient status (OR=2.3 [1.2–4.4]) and SVT on non-varicose veins (OR=1.8 [1.1–2.7]) were significantly and independently associated with an increased risk of concurrent DVT. 39.4% of SVT on non-varicose veins presented a concurrent DVT. However, varicose vein status did not influence the three-month prognosis as rates of death, symptomatic venous thromboembolic (VTE) recurrence and major bleeding were equivalent in both non-varicose and varicose SVTs (1.4% vs. 1.1%; 3.4% vs. 2.8%; 0.7% vs. 0.3%). Only male gender (OR=3.5 [1.1–11.3]) and inpatient status (OR=4.5 [1.3–15.3]) were independent predictive factors for symptomatic VTE recurrence but the number of events was low (n=15, 3.0%). Three-month numbers of deaths (n=6, 1.2%) and of major bleedings (n=2, 0.4%) were even lower, precluding any relevant interpretation. In conclusion, SVT on non-varicose veins and some classical risk factors for DVT were predictive factors for concurrent DVT at presentation. As SVT remains mostly a clinical diagnosis, these data may help selecting patients deserving an ultrasound examination or needing anticoagulation while waiting for diagnostic tests. Larger studies are needed to evaluate predictive factors for adverse outcome.

Keywords

Superficial vein thrombosis - thrombophlebitis - deep-vein thrombosis - pulmonary embolism - varicose veins

* A list of the OPTIMEV SMFV Study investigators is available online at www.thrombosis-online.com.


 

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