Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis

Andreas Stein; Felix Mohr; Magdalena Laux; Stefanie Thieme; Barbara Lorenz; Mirijam Cetindis; Janina Hackl; Philipp Groha; Gabriele Demetz; Stefanie Schulz; Julinda Mehilli; Albert Schömig; Adnan Kastrati; Ilka Ott

doi:10.1160/TH11-08-0552

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 107(04): 769-774
DOI: 10.1160/TH11-08-0552

Cardiovascular Biology and Cell Signalling

Schattauer GmbH

Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis

Andreas Stein

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Felix Mohr

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Magdalena Laux

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Stefanie Thieme

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Barbara Lorenz

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Mirijam Cetindis

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Janina Hackl

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Philipp Groha

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Gabriele Demetz

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Stefanie Schulz

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Julinda Mehilli

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Albert Schömig

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Adnan Kastrati

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

,

Ilka Ott

¹Deutsches Herzzentrum der Technischen Universität München, München, Germany

› Author Affiliations

Abstract

Summary

Erythropoietin improves myocardial function and enhances re-endothelialisation. Aim of this study was to analyse progenitor cell mobilisation and restenosis in patients from the Regeneration of Vital Myocardium in ST-Segment Elevation Myocardial Infarction by Erythropoietin (REVIVAL-3) study. Patients with STEMI undergoing percutaneous coronary intervention (PCI) were randomly assigned to Epoetin beta (EPO) (n=68) or placebo (n=70). Drug-eluting stents (DES) were utilised in 93% of patients receiving EPO and in 95% of patients receiving placebo (p=0.83). Serial venous blood samples were drawn; CD133+ progenitor cells were quantified by four-colour flow cytometry and cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12 and tumour necrosis factor (TNF) alpha were analysed by cytometric bead array. Fortyeight hours after PCI a significant increase in CD133+ progenitor cells was observed in the EPO group. Yet, no differences in plasma cytokines were found. Quantitative coronary angiography after six months revealed an increase in segment diameter stenosis in the EPO group (32 ± 19% vs. 26 ± 14%, p=0.046). However, this increase in neointima generation was not associated with progenitor cell mobilisation. EPO in patients with STEMI treated with PCI is associated with an increase in diameter stenosis that is not associated with circulating progenitor cells.

ClinicalTrials.gov Identifier: NCT00390832

Keywords

Myocardial infarction - restenosis - progenitor cells

Full Text

References

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