Monocyte function and trafficking in cardiovascular disease

Evangelia Pardali; Johannes Waltenberger

doi:10.1160/TH12-04-0276

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2012; 108(05): 804-811
DOI: 10.1160/TH12-04-0276

Theme Issue Article

Schattauer GmbH

Monocyte function and trafficking in cardiovascular disease

Evangelia Pardali

¹Department Cardiovascular Medicine, University of Münster, Münster, Germany

,

Johannes Waltenberger

¹Department Cardiovascular Medicine, University of Münster, Münster, Germany

› Author Affiliations

Abstract

Summary

Monocytes are key effectors of the immune homeostasis and play a crucial role in (vascular) injury repair. Despite their role in immune defense and tissue repair mechanisms, monocytes are also involved in several pathological conditions such as autoimmune and cardiovascular diseases as well as cancer. This suggests that monocytes can be used as diagnostic and as therapeutic targets. A better understanding and characterisation of monocytes and their function in both physiological and pathological situations is thus of great interest. This review focuses on recent advances on the role of monocytes in cardiovascular diseases and describes the value of monocytes as either disease marker or therapeutic target for (cardio)vascular diseases.

Keywords

Monocytes - cardiovascular disease - atherosclerosis - myocardial infarction

Full Text

References

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