Download PDF
Thromb Haemost 2012; 108(03): 410-411
DOI: 10.1160/TH12-06-0435
Current Controversies
Schattauer GmbH

Outcomes of positive randomised controlled clinical trials: Double-blind or double vision?

Editorial on Serebruany, Atar: ‘Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials – Common patterns in TRITON, RECORD, and PLATO?’ (Thromb Haemost 2012; 108.3)
Freek W. A. Verheugt
1   Department of Cardiology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, Netherlands
› Author Affiliations
Further Information

Publication History

Received: 26 June 2012

Accepted after minor revision: 03 July 2012

Publication Date:
25 November 2017 (online)

Also available at
    Permissions and Reprints

Editorial Focus on ► Serebruany, Atar. Thromb Haemost 2012; 108: 412-414.

 

  • References

  • 1 Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-2471.
    CrossrefPubMedGoogle Scholar
  • 2 Home PD, Pocock SJ, Beck-Nielsen H. et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009; 373: 2125-2135.
    CrossrefPubMedGoogle Scholar
  • 3 Wiviott SD, Braunwald E, McCabe CH. et al. Prasugrel versus clopidog rel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-2015.
    CrossrefPubMedGoogle Scholar
  • 4 Wallentin L, Becker RC, Budaj A. et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-1057.
    CrossrefPubMedGoogle Scholar
  • 5 Serebruany VL, Atar D. Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials: common patterns in TRITON, RECORD and PLATO. Thromb Haemost 2012; 108: 412-414.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Serebruany VL. Viewpoint: paradoxical excess mortality in the PLATO trial should be independently verified. Thromb Haemost 2011; 105: 752-759.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Wallentin L, Becker RC, James SK. et al. The PLATO trial reveals further opportunities to improve outcomes in patients with acute coronary syndrome. Thromb Haemost 2011; 105: 760-762.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Ohman EM, Roe MT. Explaining the unexpected: insights from the PLATelet inhibition and clinical Outcomes (PLATO) trial comparing ticagrelor and clopidogrel. Thromb Haemost 2011; 105: 763-765.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525-2538.
    CrossrefPubMedGoogle Scholar