Adipose tissue-derived PAI-1: A molecular link for thrombo-inflammatory disease states?

Insight on Ekström et al. Thromb Haemost 2012; 108: 485–492.

• References

• 1 Northcott JM. et al. Adipokines and the cardiovascular system: mechanisms mediating health and disease. Can J Physiol Pharmacol 2012; 90: 1029-1059.
• 2 Fain JN. Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010; 2010: 513948.
• 3 Samad F, Loskutoff DJ. The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost 1997; 78: 652-655.
• 4 Zaidi M. et al. Minireview: The link between fat and bone: does mass beget mass?. Endocrinology 2012; 153: 2070-2075.
• 5 Ekström M. et al. Stimulated in vivo synthesis of plasminogen activator inhibitor-1 in human adipose tissue. Thromb Haemost 2012; 108: 485-492.
• 6 Nieswandt B. et al. Ischaemic stroke: a thrombo-inflammatory disease?. J Physiol 2011; 589: 4115-4123.
• 7 Van De Craen B. et al. The biochemistry, physiology and pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo. Thromb Res. 2012 epub ahead of print.