Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)

Carlo Martinoli; Ornella Della Casa Alberighi; Giovanni Di Minno; Ermelinda Graziano; Angelo Claudio Molinari; Gianluigi Pasta; Giuseppe Russo; Elena Santagostino; Annarita Tagliaferri; Alberto Tagliafico; Massimo Morfini

doi:10.1160/TH12-11-0874

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(06): 1170-1179
DOI: 10.1160/TH12-11-0874

New Technologies, Diagnostic Tools and Drugs

Schattauer GmbH

Development and definition of a simplified scanning procedure and scoring method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)

Carlo Martinoli

¹Radiologia – DISSAL, Università di Genova, Italy

,

Ornella Della Casa Alberighi

³Direzione Scientifica – Unità di Farmacologia Clinica e Sperimentazioni Cliniche, IRCCS Istituto „G. Gaslini”, Genova, Italy

,

Giovanni Di Minno

⁵Dipartimento di Medicina Clinica e Sperimentale. Università di Napoli, Italy

,

Ermelinda Graziano

⁶Dipartimento di Medicina – Scienze dell’Invecchiamento. Università di Chieti-Pescara, Italy

,

Angelo Claudio Molinari

⁴Unità di Trombosi ed Emostasi – IRCCS Istituto „G. Gaslini”, Genova, Italy

,

Gianluigi Pasta

⁷Dipartimento di Ortopedia, Policlinico Universitario di Milano, Italy

,

Giuseppe Russo

¹Radiologia – DISSAL, Università di Genova, Italy

,

Elena Santagostino

⁸Centro di Emofila e Trombosi „AB Bonomi”, Policlinico Universitario di Milano, Italy

,

Annarita Tagliaferri

⁹Dipartimento di Medicina Interna – AOU Parma, Italy

,

Alberto Tagliafico

²Istituto di Anatomia Umana – DIMES, Università di Genova, Italy

,

Massimo Morfini

¹⁰Centro Emofilia – AOU “Careggi” Firenze, Italy

› Author Affiliations

Abstract

Summary

The aim of this study was to develop a simplified ultrasound scanning procedure and scoring method, named Haemophilia Early Arthropathy Detection with UltraSound [HEAD-US], to evaluate joints of patients with haemophilic arthropathy. After an initial consensus-based process involving a multidisciplinary panel of experts, three comprehensive and evidence-based US scanning procedures to image the elbow, knee and ankle were established with the aim to increase sensitivity in detection of early signs of joint involvement while keeping the technique easy and quick to perform. Each procedure included systematic evaluation of synovial recesses and selection of a single osteochondral surface for damage analysis. Based on expert consensus, a simplified scoring system based on an additive scale was created to define the joint status and, in perspective, to offer a tool to evaluate disease progression and monitor the result of treatment in follow-up studies.

Keywords

Haemophilic arthropathy - joints - scoring systems - ultrasonography - synovitis - osteochondral damage

Full Text

References

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