Download PDF
Thromb Haemost 2013; 110(01): 191-194
DOI: 10.1160/TH13-02-0163
Letters to the Editor
Schattauer GmbH

Location of venous thrombosis in patients with FVL or prothrombin G20210A mutations: Systematic review and meta-analysis

Francesco Dentali
1   Department of Clinical Medicine, Insubria University, Varese, Italy
,
Fulvio Pomero
2   Internal Medicine Department, Emergency Department, Santa Croce and Carle General Hospital, Cuneo, Italy
,
Valentina Borretta
2   Internal Medicine Department, Emergency Department, Santa Croce and Carle General Hospital, Cuneo, Italy
,
Monica Gianni
3   Department of Cardiology, Hospital of Tradate, Italy
,
Alessandro Squizzato
1   Department of Clinical Medicine, Insubria University, Varese, Italy
,
Luigi Fenoglio
2   Internal Medicine Department, Emergency Department, Santa Croce and Carle General Hospital, Cuneo, Italy
,
Walter Ageno
1   Department of Clinical Medicine, Insubria University, Varese, Italy
,
Domenico Prisco
4   Department of Medical and Surgical Care, University of Florence, Italy
› Author Affiliations
Further Information

Publication History

Received: 23 February 2013

Accepted: 03 March 2013

Publication Date:
30 November 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Kearon C. Natural history of venous thromboembolism. Circulation 2003; 107 (23) (Suppl. 01) I22-30.
    PubMedSearch in Google Scholar
  • 2 Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. J Thromb Haemost 2009; 7 0 (Suppl. 01) 301-304.
    CrossrefPubMedSearch in Google Scholar
  • 3 Rodeghiero F, Tosetto A. Activated protein C resistance and factor V Leiden mutation are independent risk factors for venous thromboembolism. Ann Intern Med 1999; 130: 643-650.
    CrossrefPubMedSearch in Google Scholar
  • 4 Salomon O, Steinberg DM, Zivelin A. et al. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscler Thromb Vasc Biol 1999; 19: 511-518.
    CrossrefPubMedSearch in Google Scholar
  • 5 Dentali F, Ageno W, Bozzato S. et al. Location of venous thromboembolism in patients with inherited thrombophilic abnormalities: a systematic review and a meta-analysis of the literature. J Thromb Haemost 2012; 10: 1-5.
    CrossrefPubMedSearch in Google Scholar
  • 6 Martinelli I, Cattaneo M, Panzeri D. et al. Low prevalence of factor V:Q506 in 41 patients with isolated pulmonary embolism. Thromb Haemost 1997; 77: 440-443.
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Arsov T, Miladinova D, Spiroski M. Factor V Leiden is associated with higher risk of deep venous thrombosis of large blood vessels. Croat Med J 2006; 47: 433-439.
    PubMedSearch in Google Scholar
  • 8 Leroyer C, Mercier B, Escoffre M. et al. Factor V Leiden Prevalence in Venous Thromboembolism Patients. Chest 1997; 111: 1603-1606.
    CrossrefPubMedSearch in Google Scholar
  • 9 Caprini JA, Goldshteyn S, Glase CJ. et al. Thrombophilia testing in patients with venous thrombosis. Eur J Vasc Endovasc Surg 2005; 30: 550-555.
    CrossrefPubMedSearch in Google Scholar
  • 10 Gadelha T, Roldán V, Lecumberri R. RIETE Investigators. et al. Clinical characteristics of patients with factor V Leiden or prothrombin G20210A and a first episode of venous thromboembolism. Findings from the RIETE Registry. Thromb Res 2010; 126: 283-286.
    PubMedSearch in Google Scholar
  • 11 González-Porras JR, García-Sanz R, Alberca I. et al. Risk of recurrent venous thrombosis in patients with G20210A mutation in the prothrombin gene or factor V Leiden mutation. Blood Coagul Fibrinolysis 2006; 17: 23-28.
    CrossrefPubMedSearch in Google Scholar
  • 12 Huisman MV, Klok FA, Karami RDjurabi. et al. Factor V Leiden is associated with more distal location of deep vein thrombosis of the leg. J Thromb Haemost 2008; 06: 544-545.
    CrossrefPubMedSearch in Google Scholar
  • 13 Kovac M, Mitic G, Mikovic Z. et al. Type and location of venous thromboembolism in carriers of Factor V Leiden or prothrombin G20210A mutation versus patients with no mutation. Clin Appl Thromb Hemost 2010; 16: 66-70.
    CrossrefPubMedSearch in Google Scholar
  • 14 Kupeli E, Verdi H, Simsek A. et al. Genetic mutations in Turkish population with pulmonary embolism and deep venous thrombosis. Clin Appl Thromb Hemost 2011; 17: 87-94.
    CrossrefPubMedSearch in Google Scholar
  • 15 Martinelli I, Battaglioli T, Razzari C. et al. Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophilia. J Thromb Haemost 2007; 05: 98-101.
    CrossrefPubMedSearch in Google Scholar
  • 16 Schulman S. Thrombophilia and location of venous thromboembolism. J Thromb Haemost 2007; 05: 2151-2152.
    CrossrefPubMedSearch in Google Scholar
  • 17 van Stralen KJ, Doggen CJM, Bezemer ID. et al. Mechanisms of the factor V Leiden paradox. Arterioscler Thromb Vasc Biol 2008; 28: 1872-1877.
    CrossrefPubMedSearch in Google Scholar
  • 18 Wåhlander K, Larson G, Lindahl TL. et al. Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. Thromb Haemost 2002; 87: 580-585.
    Thieme ConnectPubMedSearch in Google Scholar
  • 19 Emmerich J, Rosendaal FR, Cattaneo M. et al. Combined effect of factor V Leiden and prothrom-bin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost 2001; 86: 809-816.
    PubMedSearch in Google Scholar
  • 20 Bounameaux H. Factor V Leiden paradox: risk of deep-vein thrombosis but not of pulmonary embolism. Lancet 2000; 356: 182-183.
    CrossrefPubMedSearch in Google Scholar
  • 21 Parker AC, Mundada LV, Schmaier AH. et al. Factor V Leiden inhibits fibrinolysis in vivo. Circulation 2004; 110: 3594-3598.
    CrossrefPubMedSearch in Google Scholar
  • 22 Mosnier LO, Bouma BN. Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis. Arterioscler Thromb Vasc Biol 2006; 26: 2445-2453.
    CrossrefPubMedSearch in Google Scholar
  • 23 Hertzberg MS. Genetic testing for thrombophilia mutations. Semin Thromb Hemost 2005; 31: 33-38.
    Thieme ConnectPubMedSearch in Google Scholar
  • 24 Colucci M, Binetti BM, Tripodi A. et al. Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism. Blood 2004; 103: 2157-2161.
    CrossrefPubMedSearch in Google Scholar