Atheroprotective Krüppel-like factor 4 is downregulated in monocyte subsets of patients with coronary artery disease

Frauke S. Czepluch; Hendrik Kuschicke; Claudia Dellas; Joachim Riggert; Gerd Hasenfuss; Katrin Schäfer

doi:10.1160/TH13-05-0367

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 110(05): 1080-1082
DOI: 10.1160/TH13-05-0367

Letters to the Editor

Schattauer GmbH

Atheroprotective Krüppel-like factor 4 is downregulated in monocyte subsets of patients with coronary artery disease

Frauke S. Czepluch

¹Department of Cardiology and Pulmonary Medicine, University Medical Center Göttingen, Göttingen, Germany

,

Hendrik Kuschicke

¹Department of Cardiology and Pulmonary Medicine, University Medical Center Göttingen, Göttingen, Germany

,

Claudia Dellas

¹Department of Cardiology and Pulmonary Medicine, University Medical Center Göttingen, Göttingen, Germany

,

Joachim Riggert

²Department of Transfusion Medicine, University Medical Center Göttingen, Göttingen, Germany

,

Gerd Hasenfuss

¹Department of Cardiology and Pulmonary Medicine, University Medical Center Göttingen, Göttingen, Germany

,

Katrin Schäfer

¹Department of Cardiology and Pulmonary Medicine, University Medical Center Göttingen, Göttingen, Germany

› Author Affiliations

Abstract

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References

References
1 Cao Z, Sun X, Icli B. et al. Role of Krüppel-like factors in leukocyte development, function, and disease. Blood 2010; 116: 4404-4414.
2 Hristov M, Weber C. Differential role of monocyte subsets in atherosclerosis. Thromb Haemost 2011; 106: 757-762.
3 Liao X, Sharma N, Kapadia F. et al. Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest 2011; 121: 2736-2749.
4 Sharma N, Lu Y, Zhou G. et al. Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in apoE-/- mice – brief report. Arterioscler Thromb Vasc Biol 2012; 32: 2836-2838.
5 Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: Their role in infection and inflammation. J Leukoc Biol 2007; 81: 584-592.
6 Nahrendorf M, Swirski FK, Aikawa E. et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037-3047.
7 Zawada AM, Rogacev KS, Rotter B. et al. Super-SAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 2011; 118: e50-61.
8 Venneri MA, De Palma M, Ponzoni M. et al. Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007; 109: 5276-5285.
9 Schirmer SH, Fledderus JO, van der Laan AM. et al. Suppression of inflammatory signaling in monocytes from patients with coronary artery disease. J Mol Cell Cardiol 2009; 46: 177-185.
10 Sivapalaratnam S, Basart H, Watkins NA. et al. Monocyte gene expression signature of patients with early onset coronary artery disease. PLoS One 2012; 7: e32166
11 Sels JW, Elsenberg EH, Hoefer IE. et al. Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease. PLoS One 2012; 7: e46356