Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion

Helene Hartwig; Maik Drechsler; Dirk Lievens; Birgit Kramp; Philipp von Hundelshausen; Esther Lutgens; Christian Weber; Yvonne Döring; Oliver Soehnlein

doi:10.1160/TH13-08-0699

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 111(03): 562-564
DOI: 10.1160/TH13-08-0699

Letters to the Editor

Schattauer GmbH

Platelet-derived PF4 reduces neutrophil apoptosis following arterial occlusion

Helene Hartwig^*

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

²Department of Pathology, Academic Medical Center (AMC), Amsterdam, the Netherlands

,

Maik Drechsler^*

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Dirk Lievens

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Birgit Kramp

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Philipp von Hundelshausen

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Esther Lutgens

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

³Department of Biochemistry, Academic Medical Center (AMC), Amsterdam, the Netherlands

,

Christian Weber

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

⁴Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands

⁵DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

,

Yvonne Döring

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Oliver Soehnlein

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

²Department of Pathology, Academic Medical Center (AMC), Amsterdam, the Netherlands

⁵DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

› Author Affiliations

Abstract

Note: The editorial process for this manuscript was fully handled by Gregory Y. H. Lip, Editor in Chief.

Full Text

References

References
1 Guasti L, Dentali F, Castiglioni L. et al. Neutrophils and clinical outcomes in patients with acute coronary syndromes and/or cardiac revascularisation. A systematic review on more than 34,000 subjects. Thromb Haemost 2011; 106: 591-599.
2 Garlichs CD, Eskafi S, Cicha I. et al. Delay of neutrophil apoptosis in acute coronary syndromes. J Leukoc Biol 2004; 75: 828-835.
3 Biasucci LM, Liuzzo G, Giubilato S. et al. Delayed neutrophil apoptosis in patients with unstable angina: relation to C-reactive protein and recurrence of instability. Eur Heart J 2009; 30: 2220-2225.
4 Grommes J, Alard JE, Drechsler M. et al. Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med 2012; 185: 628-636.
5 Duerschmied D, Suidan GL, Demers M. et al. Platelet serotonin promotes the recruitment of neut-rophils to sites of acute inflammation in mice. Blood 2013; 121: 1008-1015.
6 Burkhart JM, Vaudel M, Gambaryan S. et al. The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood 2012; 120: e73-82.
7 Petersen F, Bock L, Flad HD. et al. Platelet factor 4-induced neutrophil-endothelial cell interaction: involvement of mechanisms and functional consequences different from those elicited by IL-8. Blood 1999; 94: 4020-4028.
8 Drechsler M, Megens RT, van Zandvoort M. et al. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation 2010; 122: 1837-1845.
9 Karshovska E, Weber C, von Hundelshausen P. Platelet chemokines in health and disease. Thromb Haemost 2013; 110: 894-902.
10 Isner JM. Tissue responses to ischemia: local and remote responses for preserving perfusion of ischemic muscle. J Clin Invest 2000; 106: 615-619.
11 Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res 2012; 110: 159-173.
12 Duffin R, Leitch AE, Fox S. et al. Targeting granu-locyte apoptosis: mechanisms, models, and therapies. Immunol Rev 2010; 236: 28-40.
13 Ortega-Gómez A, Perretti M, Soehnlein O. Resolution of inflammation: an integrated view. EMBO Mol Med 2013; 5: 661-674.

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