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Thromb Haemost 2014; 111(06): 1060-1066
DOI: 10.1160/TH13-09-0757
Platelets and Blood Cells
Schattauer GmbH

Association between the rs342293 polymorphism and adverse cardiac events in patients undergoing percutaneous coronary intervention

Jolanta M. Siller-Matula
1   Department of Cardiology, Medical University of Vienna, Austria
,
Iciar Arbesu
2   Department of Laboratory Medicine, Medical University of Vienna, Austria
,
Bernd Jilma
3   Department of Clinical Pharmacology, Medical University of Vienna, Austria
,
Gerald Maurer
1   Department of Cardiology, Medical University of Vienna, Austria
,
Irene M. Lang
1   Department of Cardiology, Medical University of Vienna, Austria
,
Christine Mannhalter
2   Department of Laboratory Medicine, Medical University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received: 14 September 2013

Accepted after major revision: 16 January 2014

Publication Date:
21 November 2017 (online)

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Summary

The single nucleotide polymorphism (SNP) rs342293 has been shown to influence platelet number and mean platelet volume (MPV). We investigated the association between the rs342293 polymorphism and cardiovascular outcome in a prospective cohort study. The rs342293 polymorphism was analysed in 404 patients with coronary artery disease undergoing percutaneous coronary intervention. The rates of cardiac adverse events were recorded during two years of follow-up. The polymorphism was associated with MPV (median 10.1 fL, interquartile range [IQR]: 9.6 to 10.6 in patients with the CC-allele vs 10.4 fL, IQR: 9.9 to 11.1 in G>C SNP carriers; p<0.001), but not with platelet count. Survival analysis indicated that carriers of the rs342293 G variant had a substantially higher risk to develop cardiac adverse events compared with wild type carriers during two years of follow-up (33% vs 22%; adjusted hazard ratio = 1.63, 95% confidence interval = 1.06–2.52, p=0.027). The rs342293 SNP could explain 2.9% of the variability in MPV (p=0.01). In conclusion, patients undergoing coronary stenting who carry the G-variant of the rs342293 SNP which is associated with larger MPV are at higher risk for adverse cardiovascular outcome.

Keywords

Platelet aggregation - polymorphism - genetic - outcome assessment (healthcare) - platelet count - myocardial Infarction
 

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