Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population

Marion Andro; Aurélien Delluc; Marie-Pierre Moineau; Cécile Tromeur; Maelenn Gouillou; Karine Lacut; Jean-Luc Carré; Armelle Gentric; Grégoire Le Gal

doi:10.1160/TH15-02-0148

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2016; 115(01): 169-175
DOI: 10.1160/TH15-02-0148

Stroke, Systemic or Venous Thromboembolism

Schattauer GmbH Schattauer

Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population

A case-control study

Authors

Marion Andro

¹Université de Bretagne Occidentale, EA 3878, Brest, France

²CHRU Brest, Département de gériatrie, Brest, France
Aurélien Delluc

¹Université de Bretagne Occidentale, EA 3878, Brest, France
Marie-Pierre Moineau

³CHRU Brest, Département de biochimie, Brest, France
Cécile Tromeur

¹Université de Bretagne Occidentale, EA 3878, Brest, France
Maelenn Gouillou

⁴INSERM, Centre d’investigation clinique CIC 1412, Brest, France
Karine Lacut

¹Université de Bretagne Occidentale, EA 3878, Brest, France

⁴INSERM, Centre d’investigation clinique CIC 1412, Brest, France
Jean-Luc Carré

³CHRU Brest, Département de biochimie, Brest, France
Armelle Gentric

²CHRU Brest, Département de gériatrie, Brest, France

⁵Université de Bretagne Occidentale, EA 4686, Brest, France
Grégoire Le Gal

¹Université de Bretagne Occidentale, EA 3878, Brest, France

⁶Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada

Abstract

Summary

The prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population.

Keywords

Vitamin D - venous thromboembolism - aged - risk factors - case-control study

Full Text

References

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