Onset of optimal P2Y12-ADP receptor blockade after ticagrelor and prasugrel intake in Non-ST elevation acute coronary syndrome

Laurent Bonello; Marc Laine; Laurence Camoin-Jau; Frederic Noirot; Régis Guieu; Françoise Dignat-George; Franck Paganelli; Corinne Frere

doi:10.1160/TH15-02-0149

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2015; 114(04): 702-707
DOI: 10.1160/TH15-02-0149

Cellular Haemostasis and Platelets

Schattauer GmbH

Onset of optimal P2Y12-ADP receptor blockade after ticagrelor and prasugrel intake in Non-ST elevation acute coronary syndrome

Laurent Bonello

¹Département de cardiologie, Hôpital universitaire Nord de Marseille, Assistance-Publique Hôpitaux de Marseille, Marseille, France

²Vascular Research Center of Marseille, INSERM UMR-S 1076, Aix-Marseille Université, Marseille, France

,

Marc Laine

¹Département de cardiologie, Hôpital universitaire Nord de Marseille, Assistance-Publique Hôpitaux de Marseille, Marseille, France

,

Laurence Camoin-Jau

³Laboratoire d’hématologie Hôpital de la Timone, Marseille, France

,

Frederic Noirot

¹Département de cardiologie, Hôpital universitaire Nord de Marseille, Assistance-Publique Hôpitaux de Marseille, Marseille, France

,

Régis Guieu

⁴Research Unit of Physiology and Pathophysiology in Extreme Oxygenation Conditions (UMR MD2), Faculty of Medicine, Aix-Marseille University, Marseille, France

,

Françoise Dignat-George

²Vascular Research Center of Marseille, INSERM UMR-S 1076, Aix-Marseille Université, Marseille, France

⁵Laboratoire d‘Hématologie et de Biologie Vasculaire, Assistance-Publique Hôpitaux de Marseille, Centre hospitalo-universitaire de la Conception, Marseille, France

,

Franck Paganelli

¹Département de cardiologie, Hôpital universitaire Nord de Marseille, Assistance-Publique Hôpitaux de Marseille, Marseille, France

,

Corinne Frere

²Vascular Research Center of Marseille, INSERM UMR-S 1076, Aix-Marseille Université, Marseille, France

³Laboratoire d’hématologie Hôpital de la Timone, Marseille, France

› Author Affiliations

Abstract

Summary

Pretreatment with a loading dose (LD) of clopidogrel or ticagrelor before percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) is supported by the guidelines, but debated following a recent meta-analysis on clopidogrel pretreatment and the ACCOAST trial. In this trial prasugrel pretreatment failed to reduce ischaemic events. The timing of optimal platelet reactivity (PR) inhibition of ticagrelor and prasugrel in non ST-elevation ACS (NSTE ACS) is yet undetermined. In the present study, we aimed to investigate the delay required to reach optimal PR inhibition in NSTE ACS following a LD of ticagrelor or prasugrel. Consecutive patients undergoing PCI for NSTE ACS were randomised in this monocentre study. The Vasodilatorphosphoprotein index (VASP) was used to measure PR before the LD and then at 30 minutes, 1, 2, 4 and 24 hours (h) post-LD. Optimal PR inhibition was defined as a VASP< 50 %. We randomised 24 patients to ticagrelor or prasugrel LD. One hour after the LD, 29 % of patients had a VASP > 50 % (ticagrelor and prasugrel: 25 vs 33 %; p=0.7). Optimal PR inhibition was obtained 2 h after the LD in both groups (12/12 with ticagrelor and 11/12 with prasugrel). At that time, the mean VASP index was 19 ± 16 % (95 %CI: 12–25). Maximal PR inhibition was reached after 4 h: 11 ± 10 % (95 %CI: 6–15). In NSTE ACS undergoing PCI a LD of ticagrelor or prasugrel given during the procedure provides optimal P2Y12-ADP receptor blockade in 2 h and maximal inhibition within 4 h.

Keywords

P2Y12-ADP receptor - vasodilator-phophoprotein - thrombosis - pretreatment

Full Text

References

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