Clinical practice guidelines for prophylaxis of venous thomboembolism in cancer patients

Corinne Frere; Dominique Farge

doi:10.1160/TH16-04-0302

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2016; 116(04): 618-625
DOI: 10.1160/TH16-04-0302

Theme Issue Article

Schattauer GmbH

Clinical practice guidelines for prophylaxis of venous thomboembolism in cancer patients

Corinne Frere

¹Assistance Publique Hôpitaux de Marseille, Timone Hospital, Service d’Hematologie biologique, Marseille; Aix-Marseille Université, INSERM UMRS 1076, VRCM, Marseille, France

,

Dominique Farge

²Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Internal Medicine: Autoimmune and and Vascular Diseases Unit, UF 04, Paris; INSERM UMRS 1160, Paris 7 Diderot University, Sorbonne Paris Cité, Paris, France

› Author Affiliations

Abstract

Summary

Symptomatic venous thromboembolism (VTE) occurs 4-7 times more frequently in cancer patients as compared to non-cancer patients. A significant number of risk factors, which can be subcategorised as patient-, cancer- or treatment-related, have been shown to influence the risk of VTE during malignancy and further incorporated in risk-assessment models. Safe and efficient thromboprophylaxis regimens allow substantial decreased in VTE rates, since VTE is most often a largely preventable disease, but thromboprophylaxis remains underused in cancer compared to non-cancer patients. If thromboprophylaxis is warranted in cancer patients undergoing surgery or hospitalised for acute medical illness or with a lower mobility in the absence of contraindications to anticoagulants, its benefit remains controversial in outpatients and may be limited to locally advanced or metastatic pancreatic or lung cancer treated with chemotherapy. The International Initiative on Thrombosis and Cancer-CME free mobile app (ios and android), based on the International Clinical Practice Guidelines (CPG), facilitates their implementation and dissemination of knowledge worldwide so as to improve VTE treatment and prophylaxis in cancer patients.

Keywords

Venous thromboembolism - prophylaxis - anticoagulants - current clinical practice guidelines - risk assessment

Full Text

References

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