The History of the Data Systems AutoChemist® (ACH) and AutoChemist-PRISMA (PRISMA®): from 1964 to 1986

Summary

Objectives: This paper presents the history of data system development steps (1964 – 1986) for the clinical analyzers AutoChemist®, and its successor AutoChemist PRISMA® (PRogrammable Individually Selective Modular Analyzer). The paper also partly recounts the history of development steps of the minicomputer PDP 8 from Digital Equipment. The first PDP 8 had 4 core memory boards of 1 K each and was large as a typical oven baking sheet and about 10 years later, PDP 8 was a “one chip microcomputer” with a 32 K memory chip. The fast developments of PDP 8 come to have a strong influence on the development of the data system for AutoChemist. Five major releases of the software were made during this period (1-5 MIACH).

Results: The most important aims were not only to calculate the results, but also be able to monitor their quality and automatically manage the orders, store the results in digital form for later statistical analysis and distribute the results to the physician in charge of the patient using thesame computer as the analyzer. Another result of the data system was the ability to customize AutoChemist to handle sample identification by using bar codes and the presentation of results to different types of laboratories.

Conclusions:: Digital Equipment launched the PDP 8 just as a new minicomputer was desperately needed. No other known alternatives were available at the time. This was to become a key success factor for AutoChemist. That the AutoChemist with such a high capacity required a computer for data collection was obvious already in the early 1960s. That computer development would be so rapid and that one would be able to accomplish so much with a data system was even suspicious at the time. In total, 75; AutoChemist (31) and PRISMA (44) were delivered Worldwide The last PRISMA was delivered in 1987 to the Veteran Hospital Houston, TX USA

Keywords

Computer systems for clinical analyzers - computers in laboratory automation - barcode used to identify sample tubes - quality control in clinical laboratories - software development for PDP 8

 

• References

• 1 Skeggs Jr. LT. An automatic method for colorimetric analysis. Am J Clin Path 1957; 28: 311-22.
• 2 Skeggs Jr. LT, Hochstrasser H. Multiple Automatic Sequential Analysis. Clin Chem 1964; 10: 918-36.
• 3 Collen MF. Computer Medical Databases. The First Six Decades 1950-2010, Health Informatics, London: Springer-Verlag Limited; 2012
• 4 Collen MF. A multiphasic screening programme. In: Teeling-Smith G. editor. Surveillance and Early Diagnosis in Clinical Practice. Proceedings of Colloquium held at Magdalena College, Oxford, July 7, 1965. London: Office of Health Economics; 1966 p. 10-3.
• 5 Collen MF. Periodic health examinations using an automated multitest laboratory. JAMA 1966; 195 (Suppl. 10) 830-3.
• 6 Wilson JMG, Jungner G. Principles and Practice of Screening for Disease. World Health Organization. Geneva, Switzerland: Public Health Papers No. 34, 1968
• 7 Andersson A, Blancquaert I, Beauchamp S, Déry V. Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years. Bulletin World Health Organization 2008; 86 (Suppl. 04) 317-9.
• 8 Sheehy AM, Coursin DB, Gabbay RA. Back to Wilson and Jungner: 10 Good Reasons to screen for Type 2 Diabetes Mellitus. Mayo Clin Proc 2009; 84 (Suppl. 01) 38-42.
• 9 Jungner G. Kemisk hälsokontroll (I) som hjälpmedel vid den enskilde läkarens hälsoundersökning, som en ytterligare resurs för hälsocentralernas gruppundersökningar och som en urvalsmetod vid allmän befolkningsundersökning. [Chemical health control (I). An aid to the private physician’s health examination, a further resource for group examinations in health centers and a method of choice in general examination of the population]. Svenska Läkartidningen 1962; 59: 2297-309. In Swedish.
• 10 Jungner I. Kemisk hälsokontroll (II). Praktiska synpunkter samt resultat från ett urvalt material. [Chemical health control (II). Practical aspects with results from selected material]. Svenska läkartidningen. 1962; 59: 2309-25. In Swedish.
• 11 Jungner G. Chemical Health Screening. In: Teeling-Smith G. editor. Surveillance and Early Diagnosis in General Practice. Proceedings of Colloquium held at Magdalena College, Oxford, July 7 1965. Office of Health Economics; London: 1966. p. 14-6. Appendix 1. Jungner G., Jungner I. Chemical Health Screening, ibid. p. 44-7
• 12 Jungner G, Jungner I. Chemical Health Screening. In: Sharp CLEH, Keen H. editors. Presymptomatic Detection and Early Diagnosis – A Critical Appraisal. London: Pitman Medical Publishing Co. Ltd.; 1968. p. 67-108
• 13 The Swedish National Board of Health and Welfare.. Report by Jungner G. to the 14th Session of the Regional Committee for Europe of the WHO. Prague, September 22-26 1964 Health Screening Project in Värmland. A pilot study on Mass Screening with Application of a Chemical Test Battery. www.tekniskamuseet.se
• 14 Jungner G. Chemical Health Screening. In: Teeling-Smith G. editor. Surveillance and Early Diagnosis in General Practice. Proceedings of Colloquium held at Magdalena College, Oxford: July 7 1965. Office of Health Economics; London: 1966. Appendix II Jungner. G, Jungner. I, The Health Screening Project in Värmland. A pilot study on Mass Screening with Application of a Chemical Test Battery, ibid. p. 48-52
• 15 The Swedish National Board of Health and Welfare.. The Värmland Survey. No. 23. Stockholm: 1971
• 16 Engel A. Mass Screening for Asymptomatic Disease as a Public Health Measure, In: Perspectives in Health Planning. University of London, The Athlone Press; 1968 p. 47-69
• 17 Engel A, Malmström G. The Värmland trial, a mass health screening project. Acta Sociomed Scand 1969; 2: 61-8.
• 18 Jungner G. Automation in clinical laboratories - II. In: Dickson III JF, Brown JHU. editors. Future goals of engineering in biology and medicine. Washington, DC, September 1967. London, New York: Academic Press; 1969. p. 227-31.
• 19 Jungner I, Jungner G. The AutoChemist as a laboratory screening instrument. In: Benson ES, Strandjord P. editors. Multiple laboratory screening. New York, London: Academic Press; 1969: 71-86
• 20 Jungner G. The AutoChemist’s Performance. In: Berkley C. editor. Engineering in Medicine -Automated Multiphasic Health Testing (AMHT). Davos, Switzerland: September 14-18 1970. Engineering Foundation (New York City); 1971. p. 116-23.
• 21 Jungner I. Berättelsen om AutoChemist. [The story about the AutoChemist]. 2005 In Swedish. www.tekniskamuseet.se
• 22 Jungner I. The AutoChemist. History Division of AACC. 2011; 19 (Suppl. 03) 4-5.
• 23 Peterson HE, Jungner I. The history of the AutoChemist. Yearb Med Inform 2014; 235-43.
• 24 Peterson H. The PDP-8´s role in the AutoChemist system. The Digital Equipment Computer Users Society, Spring Symposium. Boston: May 23-25 1966 p. 15-20.
• 25 Peterson HE, Lundin P. Documenting the use of computers in Swedish health care up to 1980. Yearb Med Inform 2011; 169-74.
• 26 Hammar L. PRISMA – Ett IT-projekt i svensk laboratorieautomation.[PRISMA - A Swedish laboratory automation IT project. A report to the project: From Calculators to IT – lessons from Swedish IT history]. 2008 In Swedish. www.tekniskamuseet.se
• 27 Dexter C, Larsen M. Centralized Large-Scale Clinical Testing in a Commercial Environment. Proceedings of the IEEE. 1969; 57 (Suppl. 11) 1988-95.
• 28 Bokelund H. A Review of the AutoChemist System in a Hospital Environment. Scan J Clin Lab Invest 1974; 34 (Suppl. 140) 9-26.
• 29 MetPath Inc., Teterboro, New Jersey, USA.. Setting the Pace in Laboratory Services (1979). www.tekniskamuseet.se