Assessment of left ventricular volumes, ejection fraction and mass

Summary

Aim: We compared and delineated possible differences of model-based analysis of ECGgated SPECT using ^99mTc-sestamibi (Tc- SPECT) with ECG-gated ¹⁸F-fluorodeoxyglucose- PET (FDG-PET) for determination of enddiastolic (EDV) and end-systolic (ESV) cardiac volumes, left ventricular ejection fraction (LVEF), and myocardial mass (LVMM). Patients, methods: 24 patients (21 men; age: 54 ± 12years) with coronary artery disease underwent Tc-SPECT and FDG-PET imaging for evaluation of myocardial perfusion and viability. By using model-based analysis EDV, ESV, LVEF and LVMM were calculated from short axis images of both Tc-SPECT and FDGPET. Results: Left ventricular volumes by Tc- SPECT and FDG-PET were 176 ± 60 ml and 181 ± 59 ml for EDV, and 97 ± 44 ml and 103 ± 45 ml for ESV respectively, LVEF was 47 ± 8% by Tc-SPECT and 45 ± 9% by FDG-PET. The LVMM was 214 ± 40 g (Tc-SPECT) and 202 ± 43 g (FDG-PET) (all p = NS, paired t-test). A significant correlation was observed between Tc-SPECT and FDG-PET imaging for calculation of EDV (r = 0.93), ESV (r = 0.93), LVEF (r = 0.83) and LVMM (r = 0.72). Conclusion: ECG-gated Tc-SPECT and FDG-PET using two tracers with different characteristics (perfusion versus metabolism) showed close agreement concerning measurements of left ventricular volumes, contractile function and myocardial mass by using a model-based analysis.

Zusammenfassung

Ziel der Studie war der Vergleich der Modellbasierten Analyse von EKG-getriggerten ^99mTc-Sestamibi SPECT (Tc-SPECT) und ¹⁸F-Fluordeoxyglukose-PET (FDG-PET) Studien zur Bestimmung von linksventrikulären enddiastolischen (EDV) und endsystolischen (ESV) Volumina, der Linksventrikelfunktion (LVEF) und der myokardialen Masse (LVMM). Patienten, Methoden: 24 Patienten (21 Männer, Alter: 54 ± 12 Jahre) mit koronarer Herzkrankheit wurden mittels EKG-getriggerter Tc-SPECT und FDG-PET zur Bestimmung der myokardialen Perfusion und Vitalität untersucht. Mittels Modell-basierter Analyse wurden EDV, ESV, LVEF und LVMM aus den jeweiligen Kurzachsen- Schnitten der Tc-SPECT und FDG-PET Studien berechnet. Ergebnisse: Die mittels Tc- SPECT und FDG-PET gemessenen linksventrikulären Volumina waren jeweils 176 ± 60 ml und 181 ± 59 ml für EDV und 97 ± 44 ml und 103 ± 45 ml für ESV. Die LVEF (47 ± 8% und 45 ± 9%) und LVMM (214 ± 40 g und 202 ± 43 g) unterschieden sich ebenfalls nicht zwischen Tc-SPECT und FDG-PET (p nicht signifikant für alle paired t-Tests). Es fand sich eine signifikante Korrelation zwischen den mittels Tc-SPECT und FDG-PET errechneten Werten für EDV (r = 0.93), ESV (r = 0.93), LVEF (r = 0.83) und LVMM (r = 0.72). Schlussfolgerung: Die Modell-basierte Bildanalyse EKG-getriggerter kardialer Tc-SPECT und FDG-PET mit zwei Tracern unterschiedlicher Merkmale (Perfusion versus Stoffwechsel) zeigte gute Übereinstimmung der errechneten linksventrikulären Volumina, Auswurffraktion und myokardialen Masse.

Keywords

ECG-gated SPECT - PET - left ventricular function - ¹⁸F-fluorodeoxyglucose - FDG - technetium- ^99m-sestamibi

Schlüsselwörter

EKG-getriggerte SPECT - PET - Linksventrikelfunktion - Fluordeoxyglukose - FDG - Technetium- ^99m-Sestamibi

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