Download PDF
Vet Comp Orthop Traumatol 2010; 23(04): 277-283
DOI: 10.3415/VCOT-09-03-0036
Case Report
Schattauer GmbH

Extra- and intra-articular synovial chondromatosis and malignant transformation to chondrosarcoma

C. Díaz-Bertrana
1   Facultad de Veterinaria, Departmento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
,
I. Durall
1   Facultad de Veterinaria, Departmento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
,
M.Rial. Rial
2   Hospital Veterinario Marina Baixa SL, Alfaz del Pi, Alicante, Spain
,
J. Franch
1   Facultad de Veterinaria, Departmento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
,
P. Fontecha
1   Facultad de Veterinaria, Departmento de Medicina y Cirugía Animal, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
,
A. Ramis
3   Facultad de Veterinaria, Departamento de Sanidad Animal, Universidad Autónoma de Barcelona, Bellaterra, Barcelona, Spain
› Author Affiliations
Further Information

Publication History

Received:03 April 2009

Accepted:19 February 2010

Publication Date:
17 December 2017 (online)

Also available at
    Permissions and Reprints

Summary

Intra- and extra-articular primary synovial chondromatosis (SC) was observed in a five-year-old, entire male German Shepherd. Thousands of small cartilaginous nodules were removed from the stifle joint as well as from several adjacent muscles. Diagnosis of SC was established based on clinical, radio-graphic and biopsy results. The owner declined to have a new surgery performed for complete nodule removal and partial synovectomy. Nine months after the initial presentation, a proximal pathological intraarticular tibial fracture was observed and malignant transformation to chondrosarcoma was diagnosed after limb amputation. No metastasis was observed after 1.5 years of follow-up.

Keywords

Synovial chondromatosis - synovial chondrometaplasia - synovial osteochondromatosis - chondrosarcoma
 

  • References

  • 1 Ko E, Mortimer E, Fraire AE. Extraarticular synovial chondromatosis: review of epidemiology, imaging studies, microscopy and pathogenesis, with a report of an additional case in a child. Int J Surg Pathol 2004; 12: 273-280.
    CrossrefPubMedGoogle Scholar
  • 2 Murphey MD, Vidal JA, Fanburg-Smith JC. et al. Imaging of synovial chondromatosis with radiologic-pathologic correlation. RadioGraphics 2007; 27: 1465-1488.
    CrossrefPubMedGoogle Scholar
  • 3 Murphy FP, Dahlin DC, Sullivan CR. Articular synovial chondromatosis. J Bone Joint Surg 1962; 44: 77-86.
    CrossrefPubMedGoogle Scholar
  • 4 Roulot E, Le Viet D. Primary synovial osteochondromatosis of the hand and wrist: report of a series of 21 cases and literature review. Rev Rhum Engl Ed 1999; 66: 256-266.
    PubMedGoogle Scholar
  • 5 Karlin ChA, De Smet AA, Neff J. et al. The variable manifestations of extraarticular synovial chondromatosis. Am J Roentgenol 1981; 137: 731-735.
    CrossrefPubMedGoogle Scholar
  • 6 Hecht D, Zimmerman N, Bedford M. et al. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligant for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors 1995; 12: 223-233.
    CrossrefPubMedGoogle Scholar
  • 7 Davis RI, Foster H, Arthur K. et al. Cell proliferation studies in primary synovial chondromatosis. J Path-ol 1998; 184: 18-23.
    CrossrefPubMedGoogle Scholar
  • 8 Centrella M, McCarthy T, Canalis E. Current concepts review; transforming growth factor-beta and remodeling of bone. J Bone Joint Surg Am 1991; 73 A 1418-1428.
    CrossrefPubMedGoogle Scholar
  • 9 Iwata H, Ono S, Sato K. et al. Bone morphogenic protein induced muscle and synovium derived cartilage differentation in vitro. Clin Orthop 1993; 296: 295-300.
    PubMedGoogle Scholar
  • 10 Robinson D, Hasharoni A, Evron Z. et al. Synovial chondromatosis: the possible role of FGF 9 and FGF receptor 3 in its pathology. Int J Exp Pathol 2000; 81: 183-189.
    PubMedGoogle Scholar
  • 11 Sato J, Sergami N, Suzuki T. et al. The expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 in chondrocytes in synovial chondromatosis of the temporomandibular joint: report of two cases. Int J Oral Maxillofac Surg 2002; 31: 532-536.
    CrossrefPubMedGoogle Scholar
  • 12 Pearson CA, Pearson D, Shibahara S. et al. cDNA cloning and induction of TGF-(beta). EMBO J 1988; 7: 2977-2978.
    PubMedGoogle Scholar
  • 13 Buddingh EP, Krallman P, Neff JR. et al. Chromo-some 6 abnormalities are recurrent in synovial chondromatosis. Cancer Genet Cytogenet 2003; 140: 18-22.
    CrossrefPubMedGoogle Scholar
  • 14 Bertoni F, Unni K, Beabout JW. et al. Chondrosarcoma of the synovium. Cancer 1991; 67: 155-162.
    CrossrefPubMedGoogle Scholar
  • 15 Davis RI, Hamilton A, Biggart JD. Primary synovial chondromatosis: a clinicopathologic review and assessment of malignant potencial. Hum Pathol 1998; 29: 683-688.
    CrossrefPubMedGoogle Scholar
  • 16 Wittkop B, Davies AM, Mangham DC. Primary synovial chondromatosis and synovial chondrosarcoma. Eur Radiol 2002; 12: 2112-2119.
    CrossrefPubMedGoogle Scholar
  • 17 Sperling BL, Angel S, Stoneham G. et al. Synovial chondromatosis and chondrosarcoma: a diagnostic dilemma. Sarcoma 2003; 7: 69-73.
    CrossrefPubMedGoogle Scholar
  • 18 Kirk MD. Radiographic and histologic appearance of synovial osteochondromatosis of the femorotibial bursae in a horse- a case history report. Vet Radiol 1982; 23: 167-170.
    CrossrefPubMedGoogle Scholar
  • 19 Schmidt von E, Schneider J. Ein fall von chondromatosis synovialis beim pferd. Monatsh Veterin-armed 1982; 37: 509
    PubMedGoogle Scholar
  • 20 McIlwraith CW. Synovial osteochondromatosis. In Stashak TS. editor). Adams Lameness in Horses. Philadelphia, Pennsylvania, USA: Lea and Febiger; 1987: 422-423.
    Google Scholar
  • 21 Smith RKW, Coumbe A, Schramme MC. Bilateral synovial chondromatosis of the metatarsophalangeal joints in a pony. Equine Vet J 1995; 27: 234-238.
    CrossrefPubMedGoogle Scholar
  • 22 Schawalder P. Die synoviale osteochondromatose (synoviale chondrometaplasie) beim hund. Schweiz Arch Tierheilk 1980; 122: 673-678.
    PubMedGoogle Scholar
  • 23 Sottiaux J. Quel est votre diagnostic?. Point Vet 1986; 18: 757-759.
    PubMedGoogle Scholar
  • 24 Flo GL, Stickle RL, Dunstan RW. Synovial chondrometaplasia in five dogs. J Am Vet Med Assoc 1987; 191: 1417-1422.
    PubMedGoogle Scholar
  • 25 Gregory SP, Pearson GR. Synovial osteochondromatosis in a labrador retrevier bitch. J Small Anim Pract 1990; 31: 580-583.
    CrossrefPubMedGoogle Scholar
  • 26 Edinger DT, Manley PA. Arthrodesis of the shoulder for synovial ostechondromatosis. J Small Anim Pract 1998; 39: 397-400.
    CrossrefPubMedGoogle Scholar
  • 27 Keally JK. Diagnostic Radiology of the Dog and Cat. Philadelphia, Pennsylvania, USA: W.B. Saunders Philadelphia 1979; 371
    PubMedGoogle Scholar
  • 28 Hubler M, Johnson KA, Burling RT. et al. Lesions resembling osteochondromatosis in two cats. J Small Anim Pract 1986; 27: 181-187.
    CrossrefPubMedGoogle Scholar
  • 29 Thompson KG, Pool RR. Tumors of Joints. In Meuten DJ. editor). Tumors in Domestic Animals. Iowa, USA: Blackwell Publishing Co; 2002: 283-292.
    Google Scholar
  • 30 Craig LE, Julian ME, Ferracone JD. The diagnosis and prognosis of synovial tumors in dogs: 35 cases. Vet Pathol 2002; 39: 66-73.
    CrossrefPubMedGoogle Scholar
  • 31 Szendroi M, Deodhar A. Synovial neoformations and tumors. Baillière’s Clinical Rheumatology 2000; 14: 363-383.
    PubMedGoogle Scholar
  • 32 Yamate J, Aota M, Kuwamura M. et al. Synovial sarcoma of the tendon and tendon sheath in a dog. J Vet Med Sci 2006; 68: 983-986.
    CrossrefPubMedGoogle Scholar
  • 33 Kay PR, Freemon AJ, Davies DRA. The aetiology of multiple loose bodies. Snow storm knee. J Bone Joint Surg (Br) 1989; 71 B 501-504.
    PubMedGoogle Scholar
  • 34 Ryan RS, Harris AC, O’Connell JX. et al. Synovial osteochodromatosis: the spectrum of imaging findings. Austral Rad 2005; 49: 95-100.
    PubMedGoogle Scholar
  • 35 Norman A, Steiner GC. Bone erosion in synovial chondromatosis. Radiology 1986; 161: 749-752.
    CrossrefPubMedGoogle Scholar
  • 36 Batheja NO, Wang BY, Springfield D. et al. Fine-needle aspiration diagnosis of synovial chondromatosis of the tibiofibular joint. Ann Diag Pathl 2000; 4: 77-80.
    PubMedGoogle Scholar
  • 37 Ogilvie-Harris DJ, Saleh K. Generalized synovial chondromatosis of the knee: a comparison of removal of the loose bodies alone with arthroscopic synovectomy. Arthroscopy 1994; 10: 166-170.
    CrossrefPubMedGoogle Scholar
  • 38 Maurice H, Crone M, Watt I. Synovial chondromatosis. J Bone Joint Surg Br 1988; 70: 807-811.
    CrossrefPubMedGoogle Scholar
  • 39 Lim SJ, Chung HW, Choi YL. et al. Operative treatment of primary synovial osteochondromatosis of the hip. J Bone Joint Surg Am 2006; 88: 2456-2464.
    CrossrefPubMedGoogle Scholar
  • 40 Shpitzer T, Ganel A, Engelberg S. Surgery for synovial chondromatosis: 26 cases followed up for 6 years. Acta Othop Scand 1990; 61: 567-569.
    CrossrefPubMedGoogle Scholar
  • 41 Milgram JW. Synovial chondromatosis. J Bone Joint Surg (Am) 1977; A:59: 792-801.
    CrossrefPubMedGoogle Scholar
  • 42 Swan EF, Owens Jr WF . Synovial chondrometaplasia: a case report with spontaneous regression and a review of the literature. South Med J 1972; 65: 1496-1500.
    CrossrefPubMedGoogle Scholar
  • 43 Fetsch JF, Vinh TN, Remotti F. et al. Tenosynovial (extraarticular) chondromatosis: an analysis of 37 cases of an underrecognized clinicopathologic entity with a strong predilection for the hands and feet and a high local recurrence rate. Am J Surg Pathol 2003; 27: 1260-1268.
    CrossrefPubMedGoogle Scholar
  • 44 Ritchman JD, Rose DJ. The role of arthroscopy in the management of synovial chondromatosis of the shoulder: a case report. Clin Orthop Relat Res 1990; 257: 91-93.
    PubMedGoogle Scholar
  • 45 Chong CCW, Kneebone A, Kirsh G. Radiotherapy in the management of recurrent synovial chondromatosis. Australasian Radiology 2007; 51: 95-98.
    CrossrefPubMedGoogle Scholar