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Vet Comp Orthop Traumatol 2011; 24(05): 389-397
DOI: 10.3415/VCOT-11-03-0047
Case Report
Schattauer GmbH

Massive osteolysis in a dog resembling Gorham’s disease in humans

M. Farrell
1   Fitzpatrick Referrals, Halfway Lane Eashing, Godalming, Surrey, United Kingdom
,
S. Lindsay
2   The University of Sydney – Veterinary Pathology Diagnostic Services, Sydney, New South Wales, Australia
,
V. Johnson
3   Vet CT Specialists Ltd., Comberton, Cambridgeshire, United Kingdom
,
G. Child
4   Small Animal Specialist Hospital, Sydney, New South Wales, Australia
› Author Affiliations
Further Information

Publication History

Received: 26 March 2011

Accepted: 15 June 2011

Publication Date:
17 December 2017 (online)

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Summary

An eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic limb lameness. Radiographic and computed tomographic examinations demonstrated an osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up including serial radiographic skeletal survey, biopsy, routine laboratory investigation and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed to reveal any underlying cause for the osteolysis. Conservative treatment using the bisphosphonate drug alendronate and oral analgesic medications resulted in a return to nearly normal long-term function, despite massive lumbar and pelvic osteolysis. The clinical, radiological and histopathological features in this dog are reported, and similarities with the human condition known as Gorham’s disease are discussed.

Keywords

Osteolysis - Gorham’s disease - dog - idiopathic
 

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