Massive osteolysis in a dog resembling Gorham’s disease in humans

M. Farrell; S. Lindsay; V. Johnson; G. Child

doi:10.3415/VCOT-11-03-0047

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2011; 24(05): 389-397
DOI: 10.3415/VCOT-11-03-0047

Case Report

Schattauer GmbH

Massive osteolysis in a dog resembling Gorham’s disease in humans

M. Farrell

¹Fitzpatrick Referrals, Halfway Lane Eashing, Godalming, Surrey, United Kingdom

,

S. Lindsay

²The University of Sydney – Veterinary Pathology Diagnostic Services, Sydney, New South Wales, Australia

,

V. Johnson

³Vet CT Specialists Ltd., Comberton, Cambridgeshire, United Kingdom

,

G. Child

⁴Small Animal Specialist Hospital, Sydney, New South Wales, Australia

› Author Affiliations

Abstract

Summary

An eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic limb lameness. Radiographic and computed tomographic examinations demonstrated an osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up including serial radiographic skeletal survey, biopsy, routine laboratory investigation and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed to reveal any underlying cause for the osteolysis. Conservative treatment using the bisphosphonate drug alendronate and oral analgesic medications resulted in a return to nearly normal long-term function, despite massive lumbar and pelvic osteolysis. The clinical, radiological and histopathological features in this dog are reported, and similarities with the human condition known as Gorham’s disease are discussed.

Keywords

Osteolysis - Gorham’s disease - dog - idiopathic

Full Text

References

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