Key-words:
Dural attachment - extraaxial lesion - intravascular papillary endothelial hyperplasia
- posterior fossa tumor
Introduction
Intravascular papillary endothelial hyperplasia (IPEH) (Masson's tumor) was first
described by Pierre Masson in 1923, who named it “hemangioendotheliome vegetant intravasculaire.”[[1]] IPEH is known as an unusual benign tumor defined as a form of nonneoplastic endothelial
proliferation found in organizing intravascular thrombus and less common, in extravascular
hematomas.[[2]] The deep vascular inner layers of skin, of the neck and the head regions, are the
most frequent sites for IPEH.[[3]] In this article, we present the first case of IPEH that originates from the tentorium.
Management of IPEH should be complete excision if it is possible.
Case Report
We report a case of 56-year-old male who presented with a sudden onset of headache,
dizziness, and gait imbalance that gradually increased in 15 days. Romberg's sign,
dysdiadochokinesis, and ataxia were positive. Investigations including magnetic resonance
imaging (MRI) demonstrated a right-sided lesion attached to the tentorium. It did
not have edema but there was evidence of a hematoma beginning from the lesion, and
extending to the left cerebellum through the tentorium. Postcontrast T1-weighted images
showed mostly peripheral contrast-enhancing lesion which was partly attached to the
tentorium [[Figure 1]]. The patient underwent a right paramedian suboccipital craniectomy. Infratentorial
supracerebellar approach was performed. Following the relaxation of the cerebellum
and opening the supracerebellar corridor, the lesion was seen 3 cm in depth in a close
anatomical relationship with the tentorium, which is not expected in such intraaxial
lesion [[Figure 2]]. The lesion was well-circumscribed and originating from the tentorium which is
not usual. The lesion had a tight relationship with the tentorium and attached to
the tentorium firmly. As the first step, it is planned to disconnect the lesion from
the tentorium in order to mobilize and free the lesion from its superior surface.
There were large dilated drainage veins around the lesion which were easily identified.
Our attention was focused on preserving these vessels by exposing the tumor circumferentially
until the total arterial devascularization of the tumor. Most of the arterial feeders
of the tumor were originating from the dura. After the coagulation of these arterial
feeders, entire venous structures were also coagulated and dissected. Thus, the disconnection
of the origin of the tumor which was the tentorium was achieved and the devascularization
was carried out. The initial part of this surgery can be assessed as the crucial surgical
step in terms of providing safe and controlled surgery since the tumor was avascularized.
There was a thiny epiarachnoid space between tumor and cerebellar parenchyma which
is one of the main features of extraaxial lesions. Due to the effective cerebellar
relaxation, peritumoral dissection was performed easily, remaining feeders were coagulated,
and tumor was totally removed en bloc [[Figure 3]]. Intraoperatively, hematoma extending along the tentorium was seen. The mass contained
vascular structures.{Figure 1}{Figure 2}{Figure 3}
Figure 1: (a-d) Preoperative magnetic resonance images (a) axial unenhanced T2 weighted magnetic
resonance imaging showing right-sided lesion (white arrow) and hyperdense areas which
extends to the left cerebellum (hemorrhage) and there is no edema round the lesion.
(b) Axial postcontrast T1 image, showing bilateral vermian lesions in which the right-sided
mass is enhancing gadolinium peripherally. (c) Postcontrast sagittal image, demonstrating
partly attachment of the mass to the tentorium. (d) Postcontrast coronal image demonstrates
bilateral lesions close to the tentorium in mixt intensity
Figure 2: (a-d) Intraoperative images. (a) Initial surgical view of the tumor, originating
from the tentorium (white arrow) after retraction of cerebellum inferiorly. (b) Bipolar
coagulation of the tumor feeders and detachment of the tumor from the tentorium. (c)
Surgical view of the tumor (white arrow) after total detachment. (d) Removal of the
tumor in a single piece (white arrow) fashion
Figure 3: (a-c) Postoperative magnetic resonance images demonstrating no residual tumor. (a)
Axial enhanced T1 imaging. (b) Sagittal enhanced T1 imaging. (c) Coronal T2 imaging
Standard histopathological slides were performed, and additional immunohistochemistry
was added. On Hematoxylin and Eosin staining slides, the mass was composed of fibrovascular
tissue with numerous large, anomalous blood vessels. In some areas, larger blood vessels
with thickened walls were also detected. The delicate papillary structures are covered
by a single layer of swollen or plump endothelial cells around a core of fibrous connective
tissue. An associated thrombus was also seen, but no significant atypia, mitotic activity,
or necrosis were present [[Figure 4]]a and [[Figure 4]]b. Staining for CD34 and CD31 highlighted endothelial cells lining papillary structures
and vascular channels [[Figure 4]]c. Stains for Epithelial membrane antigen (EMA), cytokeratin, and S-100 were negative.
These findings are compatible with the diagnosis of the IPEH within a preexisting
cavernoma.{Figure 4}
Figure 4: (a-c) Histopathological images. (a) Anomalous vascular channels, some of them are
associated thrombus and fibrosis. Well circumscribed dilated large blood vessel containing
papillary structures in the lesion is marked with an arrow, (H and E, ×40) (b) High
magnification view of the (arrow) marked area. The delicate papillary structures are
covered by a thin endothelial lining. No significant atypia, mitotic activity, or
necrosis are seen, (H and E, ×100). (c) Strong immunopositivity for CD-31 in most
of the endothelial cells lining small vessels and papillary structures CD31 ×100
The postoperative course was uneventful. The patient progressed well and was discharged
in a good condition without any complaints before the surgery. The patient was followed-up
for 5 years and no recurrence occurred. He died of lung cancer. Postoperative MRI
showed no residual mass [[Figure 3]]a,[[Figure 3]]b,[[Figure 3]]c.
Discussion
The involvement of Masson's tumor in the central nervous system is very rare. To the
best of our knowledge, intracranially only 24 cases are reported so far in the literature,
in which posterior fossa location is very rare.[[2]],[[4]],[[5]] In addition, there is no reported article before that shows the origination of
a masson tumor from the tentorium, as described in this article. Meninges, cavernous
sinus, skull base, subarachnoid space, and superior orbital fissure are the other
locations intracranially reported for IPEH.[[2]],[[4]],[[5]]
On radiological findings, these pathologies tend to mimic high-grade tumors, necessary
biopsy for diagnosis. Most cases of IPEH show contrast enhancement on MRI and computed
tomography (CT).[[2]] The lesion often presents as a circumscribed vascular mass with mild hyperdensity
on CT, hyperintense on T2 weighted MRI , and iso-to mildly hyperintense on T1-weighted
imaging.[[5]]
Intracranial IPEH might be presented with symptoms secondary to the mass effect such
as increased intracranial pressure, cranial nerve palsy, hemorrhage, and compression
of adjacent neurovascular structures. Because of its vascular nature, hemorrhage is
usually seen, as we experienced in this case.
Histopathologically differential diagnosis has to be made, especially from angiosarcoma.
Our lesion is well circumscribed and located in a vessel. However, angiosarcomas are
rarely intravascular and tend to invade surrounding tissues. Formation of multiple
papillae and predominant hypertrophy of endothelial cells are common features in angiosarcoma
and IPEH. However, necrosis, solid areas, mitotic figures, and moderate and severe
nuclear atypia are only seen in angiosarcoma. The papillary structures in our case
are covered by a single layer of swollen or plump endothelial cells around a core
of fibrous connective tissue and associated thrombus is also seen, but no significant
atypia, mitotic activity, or necrosis are present. For further confirmation of IPEH
diagnosis CD31 and CD34 are used to highlight the endothelial lining around the papillary
tufts.[[1]],[[2]]
Despite the pathogenesis of IPEH remains unclear, intracranial form is associated
with thrombosis in preexisting vascular malformation.[[2]] IPEH proliferation occurs as a response to combined arterial and venous reorganization.
Angiogenic factors and consequent chronic vascular inflammation leads to IPEH proliferation.
In our case, pathology is compatible with the diagnosis of the IPEH within a preexisting
cavernoma. In such cases, it should be reminded that surgical aim has to be focused
on total removal for curative treatment and long-term follow is needed due to slow-growing
pattern of this pathology. In this case, the lesion was totally removed which is very
important in the recurrence rate and in the necessity of adjuvant therapy. Because
theoretically in total removal, there is no place for radiosurgery, radiotherapy,
and chemotherapy.[[2]]
IPEH has to be considered as a benign tumor. Therefore the best prognosis is achieved
by total tumor resection. To the best of our knowledge, we presented the first case
of IPEH originating from tentorium.
Conclusion
Intracranial masson tumor is seen very rarely. Differential diagnosis has to be made
very detailed. Intracranial IPEH has to be considered as a benign tumor, therefore
the best prognosis is achieved by total tumor resection. When this is not possible
the patient can get a second (adjuvant) therapy. Because of its slow-growing pattern,
long-term follow-up is recommended.
Declaration of patient consent
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In the form the patient(s) has/have given his/her/their consent for his/her/their
images and other clinical information to be reported in the journal. The patients
understand that their names and initials will not be published and due efforts will
be made to conceal their identity, but anonymity cannot be guaranteed.
