Introduction
Verrucous carcinoma is a variant of well-differentiated squamous cell carcinoma (SCC)
with specific clinical, pathological, and behavioral peculiarities to justify its
being regarded as a specific tumor entity.[1] It develops most frequently in the mucous membranes of the oral cavity and larynx.
The development of this tumor in the ear is particularly rare. There are only 16 cases
reported of verrucous carcinoma affecting the ear in the literature.[2] It presents as slow-growing fungating mass or irregular elevated plaque. Usually,
verrucous carcinomas develop without sex-related predominance in individuals aged
50–80 years. A full-thickness biopsy is necessary to ensure the correct diagnosis.
The treatment of choice is surgical excision. We are reporting a case of verrucous
carcinoma over the helix of the left pinna for which surgical excision was preferred
as the treatment of choice.[3]
Case Report
A 70-year-old female patient, previously farmer by occupation, presented with complaints
of a fungating growth over her left pinna for 2 years. It was insidious in onset and
was gradually progressive in size. Initially, it was smaller in size and had a papular
presentation which gradually progressed to presenting condition which had cauliflower-like
shape and approximately 3 cm × 3 cm × 2 cm [Figure 1]. The patient has had complaints of itching over the lesion since the beginning but
developed pain over the lesion during the past 1 month. The pain was dull aching,
continuous, aggravated on touch, and relieved with medication. There is no history
of trauma or burn injury or insect bite at the site of the lesion and no history of
any other similar lesions in the body. She is a known hypertensive for which she is
on medication and has addiction to tobacco use orally in the form of kharra (local
preparation of tobacco used orally) for the past 30 years.{Figure 1}
Figure 1: Cauliflower-like growth presents on the helix of the left pinna
The above mentioned growth was managed by doing an excisional biopsy along with the
underlying helical cartilage and was sent for histopathology examination, and the
local site was closed with primary suturing [Figure 2].
Figure 2: Postoperative images after excisional biopsy of verrucous growth over the
helix of the left pinna
Histopathology examination showed the image of a verrucous carcinoma (showing rete
ridges with bulldozing pattern and hyperkeratosis) without exceeding the resection
limits [Figure 3].
Figure 3: Histopathological picture of verrucous carcinoma showing hyperkeratosis
(blue arrow) and rete ridges (red arrow)
Discussion
Most of the malignancies that involve the external ear are cutaneous malignancies,
of which basal cell carcinoma (BCC), SCC, and melanoma constitute the maximum numbers.
Although skin cancer can occur in all age groups, the vast majority of patients presenting
with cutaneous carcinoma are older. The mean age of patients with BCC or SCC is near
70 years.
The incidence of skin cancer is much lower in darker-skinned ethnic groups than in
Caucasians, who represent 95% of patients. BCC represents 65%–85% of head and neck
cutaneous malignancies and a similar proportion of auricular carcinomas. SCC is the
second most common, followed by melanoma.[4]
The patient who we report here is a 70-year-old female having fungating exophytic
growth over her left auricle of the pinna [Figure 1]. There is differences in the distribution of BCCs versus SCCs. SCC arises most frequently
on the external ear and upper face, whereas BCC occurs most commonly in the midface,
followed by the ear. When these lesions appear on the auricle, 72% of the BCCs and
61% of the SCCs are confined to a single subsite of the ear. BCC is found primarily
on the posterior surface of the auricle, followed by the preauricular and then the
retroauricular areas. SCC occurs in order of decreasing frequency on the helical rim,
antihelix and triangular fossa, and posterior pinna and then the concha, lobule, or
tragus.[4]
Sun exposure is the number one risk factor for the development of cutaneous malignancies.
The correlation between sun exposure and SCC is stronger than that with BCC. The sun
is the primary source of human ultraviolet radiation and the radiation ranges in wavelength
from 200 to 400 nm and has been divided into three groups. Ultraviolet A rays (320–400
nm) make up the majority of the ultraviolet radiation reaching the earth and therefore
produce most of the damage to our skin.[4]
Verrucous carcinoma is a variant of well-differentiated SCC with specific clinical,
pathological, and behavioral peculiarities to justify its being regarded as a specific
tumor entity.[1] Various names are used in the literature to describe this entity, including Ackerman's
tumor, Buschke–Lowenstein tumor, fibroid oral papillomatosis, epithelioma cuniculatum,
snuff dipper's cancer, and carcinoma cuniculatum.[5] It develops most frequently in the mucous membranes of the oral cavity and larynx.
The development of this tumor over and in the ear has been reported in 16 cases.[2]
Risk factors for verrucous carcinoma enumerated are smoking, human papillomavirus
6, 11, 16, and 18, infections, trauma, poor hygiene, minor emissions of irradiations,
immunodeficiency, exposure to sunlight and old scars, tobacco chewing, etc.[3] With relation to the anatomic position of the auricle, sunlight exposure can be
attributed as the key risk factor.
The patient reported in our case was a farmer by occupation, and India being a tropical
country, sunlight exposure maybe considered as the contributing factor in the development
of verrucous carcinoma. It presents as slow-growing fungating mass or irregular elevated
plaque, as in our case, it was a slow-growing fungating mass [Figure 1]. It is locally invasive and nonmetastasizing.
The treatment of choice is surgical excision because verrucous carcinomas are less
radiosensitive than typical SCCs.[3] The patient reported in our case was also treated on similar lines of excisional
biopsy with the removal of underlying cartilage, and the diagnosis was confirmed on
histopathological examination [Figure 2].
Morbidity in verrucous carcinoma is due to local aggressiveness of the tumor (consisting
in the skin and soft-tissue destruction) and perineural, muscle, and bone invasion.
Metastases in verrucous carcinoma are so rare that the mortality is more often due
to local invasion.[6]
Verrucous carcinoma has varied clinical presentation. It is made up of bland epithelial
cells that tend to heap up on the surface. The rate of malignant transformation to
SCC remains high. Although it is a locally aggressive lesion with rare nodal metastases,
the decision to do a conservative neck dissection is reserved for the hybrid type
of verrucous carcinoma.[7] It appears usually on a previous injury, often affecting the buccal mucosa. In patients
with suspicious lesions, more than one biopsy to diagnose a verrucous carcinoma may
be needed. No cervical lymph node involvement was seen in the study done by Candau-Alvarez
et al. Local resection with at least 5 mm of histological margin, without prophylactic
neck dissection allows local control of the disease.[8]
Verrucous carcinoma can also transform into SCC, which is dependent on the marked
reduction of membranous transforming growth factor beta receptor 2 (TBR-II) and their
predominant cytoplasmic location which further diminishes transforming growth factor-beta
growth inhibition which may cause the transformation.[9]
As reported in the study done by Singh et al., they had come across a verrucous carcinoma over the helix of the pinna quite similar
to the case presented by us, but there they had a correlation of the lesion with burn
injury[3] over the same site some years back, whereas in our case, we did not see any such
correlation, but the patient in our case being a farmer had a higher rate of exposure
to sunlight which may had a role in the development of the tumor over the auricle.
Another study done by Costache et al. from Romania was the verrucous carcinoma of the right auricle in an 86-year-old
female, which was consistent with our report, but there they had also come across
a smaller nodular growth, whereas our reported lesion was nodular to start with but
later turned into a fungating one.[6]
The study done by Proops et al. in England had reported verrucous carcinoma in the middle ear for which mastoidectomy
was performed, and the final diagnosis was given after histopathological correlation.[10]
The best treatment modality considered in case of verrucous carcinoma is surgical
excision with up to 5–10 mm margin, and as this tumor rarely presents with nodal metastasis,
neck dissection is considered only in some hybrid cases of verrucous carcinoma. As
compared with SCC, radiotherapy does not play much role in the treatment of verrucous
carcinoma. In fact, some studies have shown radiotherapy to induce anaplastic changes
if given in cases of verrucous carcinoma.[11] The study done by Mohan et al. also reports that verrucous carcinoma which is treated with adjuvant radiotherapy
has a worse overall survival and disease-specific survival as compared to both verrucous
carcinoma treated with surgery alone and SCC treated with surgery and adjuvant radiotherapy.[12]
Conclusion
The variant of SCC known as verrucous carcinoma is commonly found in the oral cavity
and in the larynx, whereas the ear is a rare site for the same. The diagnosis of verrucous
carcinoma should be considered in case of any mass or lesion over the ear auricle,
which should be treated with surgical excision, and the diagnosis is made by histopathological
examination.
Radiotherapy has no role in the management of verrucous carcinoma, and morbidity in
these cases is only due to local aggressiveness of the tumor and not due to metastasis.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms.
In the form, the patient has given her consent for her images and other clinical information
to be reported in the journal. The patient understands that name and initials will
not be published and due efforts will be made to conceal the identity, but anonymity
cannot be guaranteed.
