Tumours of the odontoid peg revisited

Abstract

Introduction: Tumours of the odontoid peg are rare but can potentially cause significant morbidity and mortality. Methods: A retrospective review of oncology and radiology database of tertiary orthopaedic oncology centre for all lesions affecting the odontoid peg over the last 12 years was performed. Results: We identified a total of 15 tumours involving the odontoid peg, majority being malignant. Myeloma was the most common tumour. Conclusion: Tumours of the odontoid peg are rare. Spinal surgeons and Radiologists need to be aware of them.

Keywords

Odonotid - tumour - imaging

Introduction

The odontoid process (also known as dens) is a distinctive anatomical structure that arises perpendicularly from the upper surface of the axis (C2). It articulates with the atlas (C1), forming the pivot upon which the head rotates. The dens is related to many critical neurovascular structures, and pathologies involving the dens can lead to significant morbidity, and potentially mortality.[[1]] Pathological anomalies can be congenital, degenerative, inflammatory, traumatic or neoplastic in nature.

Tumours of the odontoid peg are rare and their diagnosis and management can pose a serious challenge to clinicians. We have reviewed our experience of odontoid peg tumours at our tertiary referral Centre for Orthopaedic oncology. We report the largest case series of tumours of the dens, and discuss the demographics and imaging features, to aid radiologists and orthopaedic spinal surgeons in the detection of such rare tumours.

Methods

A retrospective review of our oncology and radiology database for all lesions affecting the odontoid peg over the last 12 years was performed. Local committee approval was obtained as a service evaluation. All non-neoplastic lesions including fractures, inflammatory and degenerative lesions were excluded from our study. Primary diagnosis was made using MRI with or without CT. Definitive diagnosis was obtained following biopsies of odontoid lesions, performed within our tertiary radiology. In patients with metastasis, biopsy was performed of areas other than the odontoid, and in multiple myeloma cases, diagnosis was made in conjunction with a myeloma screening. All the images were subsequently reviewed by a musculoskeletal radiologist with 8 years’ experience.

Results

We identified a total of 15 tumours involving the odontoid peg. There was a mean age of 57 years (11–79 years) with a male to female predominance of 1.5:1 (9 males and 6 females). Four cases underwent definitive diagnoses with biopsies within our tertiary centre. Of the 15 cases, the majority (n = 12) were malignant and the remaining three cases were benign. The most common malignant tumor was multiple myeloma (six cases). Metastasis was second with a total of three cases. There were two chordomas, one case each of chondrosarcoma and ABC within our cohort, all of which were diagnosed definitively with biopsy within our department. The benign tumours in our cohort included two hemangiomas and an aneurysmal bone cyst (ABC) [[Table 1]].

Table 1

Tumor subtypes identified within our Cohort

Tumour Subtype	(N)
Myeloma	6
Metastasis	3
Hemangioma	2
Chordoma	2
Chondrosarcoma	1
ABC	1
Total	15

Discussion

The odontoid process is an important structure that arises vertically cephalad from the body of C2 and attaches to the dorsal surface of the arch of the atlas; forming the atlanto-axial pivot joint.[[2]] It is held in place by three primary and one secondary ligament. The primary ligaments include the transverse ligament of the atlas (TL), which functions to limit anterior translation and flexion of the atlanto-axial joint, and two alar ligaments; situated ventral and cranial to the TL, that allow a 3–5 mm anterior shift of C1.[[3]] The main secondary ligament is the tectorial membrane (a continuous extension of the posterior longitudinal ligament of the vertebral column) that serves to limit over-flexion of the atlanto-axial joint. The odontoid process is related to many different anatomical structures including the spinal cord and vertebral artery. Any destruction of the dens can cause significant morbidity. Therefore, early diagnosis and management is essential.

Malignant

Multiple myeloma

Multiple myeloma (MM) is an idiopathic malignant disorder characterised by an abnormal proliferation of clonal plasma cells. It is the most common primary bone malignancy in adults, with a median age of diagnosis between 65 and 70 years.[[4]] Patients with suspected MM usually present with symptoms and signs typical of weight loss, fatigue (because of anaemia), renal insufficiency, hypercalcemia, recurrent infections and bone pain.[[5], [6]] The spine is involved in approximately 60’ of patients. This usually involves the thoracic region (between T4 and T6).[[7]] MM lesions of the dens are rare with very limited case reports in the literature.[[8], [9]]

The diagnosis of MM depends on laboratory and imaging investigations. MM of the odontoid peg is evaluated best with MRI and CT. On T1, lesions typically appear as low signal lesion and on T2, the lesion is of high signal. On post-contrast sequences, myeloma deposits exhibit contrast enhancement in the dens.[[10]]

Radiographs and computed tomography (CT) play an essential role in the assessment of risk of pathological fractures and response to treatment, the latter being more sensitive. On both modalities, MMs are sharply defined (or punched out) with endosteal scalloping [[Figures 1] and [2]].[[11]] In our case series of multiple myeloma of odontoid there were lucencies in the odontoid which consolidated with non-operative treatment (chemotherapy and brace).

Figure 1 (A and B): Myeloma. CT sagittal (A) and coronal (B) pathological fracture through sclerotic myelomatous deposit (arrow)

Figure 2: Myeloma. Sag CT showing myelomatous deposit in odontoid (arrow). Further lucent lesions in C3 and C4

The management of odontoid peg MM lesions depends on the degree of bony involvement and risk of fracture. Ideally, patients should be managed non-operatively with chemo-radiotherapy and high-dose steroids.[[8], [12]] In some cases, Halo or occipitocervical fusions may be required to stabilise the spine.

Chondrosarcoma

Chondrosarcoma is the third most common malignant bone tumour arising from precursor cartilage forming cells, or secondary from a pre-existing benign osteochondromas and echondromas.[[13], [14]] Chondrosarcomas account for 10’ of all primary bone tumours, and have a 10’ incidence in the spine.[[15], [16]] They most commonly affect the thoracic spine, and clinical presentation is dependent on the tumour size, mass effect and involvement of adjacent neurovascular structures.[[17], [18]] Chondrosarcomas of the odontoid peg, are very rare, and to the best of our knowledge, has not been reported in the literature. Elsewhere in the spine, almost all patients present with pain and can have a palpable mass, with over 50’ presenting with neurological symptoms.

The diagnosis of chondrosarcoma is highly dependent on correlation of radiological features with histological grading. On radiographs, chondrosarcomas appear as a destructive lesion with chondroid matrix.[[12]] CT enables analysis of the adjacent structures, paravertebral extension, the pattern of calcification, depicted as the characteristic ‘rings and arcs’ appearance.[[19]] MRI is useful in the assessment of extension of the tumour into the epidural and intraforaminal spaces.[[13], [20]] On T1WI, chondrosarcomas are of low signal and demonstrate lobulated high signal lesion on T2 with heterogeneous enhancement on post contrast images.[[19]]

Chondrosarcomas respond poorly to chemo-radiotherapy, and surgical resection is the treatment of choice.[[21]] The surgical management is beyond the scope of this study, however, it is worth mentioning that en bloc resection can be challenging in the management of chondrosarcomas of peg and therefore palliative decompression and radiotherapy may need to be considered.[[22]]

Chordoma

Chordomas are extremely rare, slow growing malignant tumours, with an incidence of less than 0.0005’.[[23]] They take origin from the notochord remnants,[[24]] and most commonly arise in the clivus, spine and sacrococcygeal region. 50’ of spinal chordomas are found within the cervical spine.[[25]] Although they very rarely metastasize,[[26]] chordomas are locally aggressive, often encapsulating the vertebral artery and cervical nerve roots,.[[27]] Due to the extensive nature of the disease and its slow progression, chordomas can be challenging to manage.[[28]]

Like all other tumours mentioned on this paper, chordomas are diagnosed with a combination of radiological imaging and histopathological examination. CT and radiographic findings are nonspecific but may show a well-circumscribed calcified lesion with marginal sclerosis. On T1 chordomas may show intermediate to low grade intensity, with hyperintense signal on T2 [[Figures 3] and [4]].[[29]] Imaging features of chordoma and chondrosarcoma may appear similar, as both are hyperintense on T2. In one of our case of chordoma of odontoid, the tumour mass was causing cord compression. Biopsy is often required to clinch the diagnosis and planning of the biopsy route after consultation with spinal surgeon is crucial. The preferred approach for biopsy is lateral or posterolateral avoiding injury to vertebral artery.

Figure 3 (A-C): Chordoma. Sagittal T1(A), STIR (B), CT (C) showing tumour within the odontoid (arrow)

Figure 4 (A-C): Chordoma. Sagittal T2(A), axial T2(B) and STIR (C) showing tumour within the odontoid (arrow)

Due to the rarity of these tumors, management is not standardized, but surgery was been widely accepted as the mainstay treatment of these lesions.[[30]] Treatment options include en bloc resection or more commonly intralesional resection.[[31]] Surgical management of odontoid peg lesions can be extremely challenging and may require a combined bilateral high anterior and posterior cervical approach.[[30]] However, proton therapy is being commonly used for chordomas.

Metastasis (Mets)

The spine is the most common site of bony metastasis, with 10’ found to affect the cervical vertebrae. The incidence of odontoid involvement is unknown. Spinal Mets can be osteolytic or osteosclerotic, depending on the primary lesion, of which 60’ are caused by breast, prostate or lung cancer (Ca).[[32]] These can be asymptomatic. If symptomatic, they can range from non-specific pain to symptoms of cord compression.[[33]] However, most cases of atlantoaxial metastasis present early with pain rather than with late compressive myelopathy.[[34]] Early detection is essential for the management and decrease morbidity.

Radiographic features are non-specific and can be lucent, sclerotic or mixed (lytic and sclerotic). MRI is the gold standard imaging modality for early detection and for assessment of the degree of cord compression.[[35]] The signal of lesions depends on the nature of the primary disease (osteoblastic, lytic or sclerotic) and degree of mineralisation. Osteolytic lesions, such as lung or renal carcinoma show intermediate signals on T1WI and may be hyper or isointense on T2WI. Osteoblastic (prostate or thyroid Carcinoma) and mixed lesions (Breast Carcinoma or lymphomas) appear hypointense on T1 and T2WI. The metastasis in our series were from breast, renal and prostate carcinoma [[Figure 5]].

Figure 5 (A and B): Metastasis. Sagittal T1(A) and STIR (B) showing tumour within the odontoid (arrow)

Treatment options for spinal metastasis are variable and depend on the patient’s symptoms, physiological status and spinal stability.[[36]] Patients presenting with severe pain and stable spine may be treated with radiotherapy. Surgery, such as decompression or occipito-cervical fusion, is preserved for patients deemed fit for surgery, with significant spinal cord compression and instability.[[36], [37]] One patient in our series had occipitocervical fusion and the other two were managed with a halo.

Hemangioma

Hemangiomas are benign lesions of vascular origin formed by abnormal proliferation of capillary and venous vessels.[[38]] They are the most common primary tumours of the spine,[[39]] however, their incidence in the odontoid peg is unknown, and we could only identify one case report in the literature.[[40]] Most hemangiomas are asymptomatic and often an incidental finding with an incidence as high as 27’ on MRI.[[41], [42]] 0.9–1.2’ of patients with hemangiomas are symptomatic with back pain and paraesthesia.[[43]] Hemangiomas can rarely grow to considerable size, enough to cause a risk of pathological fractures. These can be associated with extraosseous component referred to as an aggressive hemangioma. In these patients, imaging becomes critical, and is used in the evaluation of the site, size and degree of lysis.

On radiographs, hemangiomas affecting the vertebral bodies may appear as sclerotic lesions with a conspicuous trabecular pattern with vertical striations. CT imaging reveals the classical corduroy patterns consistent with hemangiomas and has the ability to evaluate the degree of bony involvement. MR imaging is the modality of choice in the assessment of soft tissue extension. Classic hemangiomas are hyperintense on T1 and T2 and low signal on STIR [[Figure 6]]. Atypical hemangiomas can be high on STIR and intermediate signal on T1 and T2. Chemical shift imaging can be helpful in diagnosing atypical hemangiomas with a signal drop off of over 20’.[[44]] These can be associated with epidural component, the so-called aggressive hemangiomas. In our experience, atypical hemangiomas are often referred to our tertiary orthopaedic oncology centre as metastasis but by utilising chemical shift imaging to decipher intralesional fat, a diagnosis of atypical hemangiomas can be made. This is especially important in odontoid as the alternative might be a percutaneous bone biopsy if it’s a solitary lesion. The treatment of hemangiomas is dependent on the size, site, location and symptoms. Patients who are at symptomatic may be offered endovascular embolization or percutaneous vertebroplasty, both of which have proven good results.[[45], [46]] Our patient with hemangioma of odontoid did not have any extraosseous component and was managed symptomatically.

Figure 6 (A-C): Hemangioma. Sagittal CT (A) and STIR (B) showing hemangioma within the odontoid (arrow)

Aneurysmal Bone Cyst (ABC)

ABCs are benign aggressive tumours of unknown etiology, presenting 1.4’ of all benign bony lesions.[[47]] These are more common in the younger population, frequently in the first two decades of life and have a minor female predilection. The incidence of ABC of the spine is 3–30’.[[48]] ABC of the odontoid peg specifically is even more rare with a limited number of cases reported in the literature.[[49], [50], [51]]

ABC of the odontoid peg presents with non-specific symptoms, including neck pain, neurological symptoms (secondary to cord compression). Therefore, imaging is required to delineate the diagnosis. On radiographs and CT, ABC appears as an expansile lucent lesion. There may be multiple internal septations, pathological fractures or collapse of the vertebral body.[[52]] MRI is more specific and demonstrates a heterogeneous lesion with classical fluid–fluid levels [[Figure 7]]. However, fluid–fluid levels can be seen on other tumour subtypes, which include giant cell tumour, chondroblastoma.[[53], [54]] Treatment options of ABC of odontoid include embolization, sclerotherapy, cryo or radiotherapy and surgical resection with instrumentation [[Figure 8]].[[55]]

Figure 7 (A-E): Aneurysmal Bone Cyst. Sagittal T2 (A), T1 (B), STIR (C) and CT (D) showing expansile lucent lesion (arrow) in odontoid. Sag CT (E) showing partial consolidation of tumour is noted after embolisation and surgery at 12 months

Figure 8 (A and B): Management of two different cases with halo (A) and occipitocervical fusion (B)

Conclusion

Tumours of the odontoid peg are rare, with limited cases reported in the literature. Due to their scarcity, their diagnosis and management can be delayed. Spinal surgeons and Radiologists need to be aware of such lesions to initiate appropriate early diagnosis and management.

Conflict of Interest

There are no conflicts of interest.

• References

• 1 Redlund-Johnell I, Pettersson H. Radiographic measurements of thecranio-vertebral region. Designed for evaluation of abnormalities in rheumatoidarthritis. Acta Radiol Diagn (Stockh) 1984; 25: 23-8
• 2 Jain N, Verma R, Garga UC, Baruah BP, Jain SK, Bhaskar SN. CT and MR imaging of odontoid abnormalities: A pictorial review. Indian J Radiol Imaging 2016; 26: 108-19
• 3 Schweitzer ME, Hodler J, Cervilla V, Resnick D. Craniovertebral junction: Normal anatomy with MR correlation. AJR Am J Roentgenol 1992; 158: 1087-90
• 4 Al-Farsi K. Multiple myeloma: An update. Oman Med J 2013; 28: 3-11
• 5 Bladè J, Fernández de Larrea C, Rosiñol L, Cibeira MT, Jimènez R, Powles R. Soft-tissue plasmacytomas in multiple myeloma: Incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol 2011; 29: 3805-12
• 6 Hameed A, Brady JJ, Dowling P, Clynes M, O’Gorman P. Bone disease in multiple myeloma: Pathophysiology and management. Cancer Growth Metastasis 2014; 7: 33-42
• 7 Tosi P. Diagnosis and treatment of bone disease in multiple myeloma: Spotlight on spinal involvement. Scientifica (Cairo) 2013; 2013: 104546
• 8 Acar EA, Demirci U, Pabusçu Y, Miskioglu HM, Aydogdu I. Pathological Fracture in Odontoid Process in Multiple Myeloma. Turk J Haematol 2017; 34: 181-2
• 9 Yamasaki T, Fujita K, Nagatomo Y, Sato Y, Yanaka K, Kamesaki T. Odontoid process fracture as the initial presentation of multiple myeloma. No To Shinkei 2004; 56: 84-5
• 10 Dutoit JC, Verstraete KL. MRI in multiple myeloma: A pictorial review of diagnostic and post-treatment findings. Insights Imaging 2016; 7: 553-69
• 11 Ormond Filho AG, Carneiro BC, Pastore D, Silva IP, Yamashita SR, Consolo FD. et al. Whole-body imaging of multiple myeloma: Diagnostic criteria. Radiographics 2019; 39: 1077-97
• 12 Sundaresan N, Galicich JH, Lane JM, Greenberg HS. Treatment of odontoid fractures in cancer patients. J Neurosurg 1981; 54: 187-92
• 13 Tessitore E, Burkhardt K, Payer M. Primary clear-cell chondrosarcoma of the cervical spine. Case illustraction. J Neurosurg Spine 2006; 4: 424
• 14 Knoeller SM, Uhl M, Gahr N, Adler CP, Herget GW. Differential diagnosis of primary malignant bone tumors in the spine and sacrum. The radiological and clinical spectrum. Neoplasma 2008; 55: 16-22
• 15 Sundaresan N, Rosen G, Boriani S. Primary malignant tumors of the spine. Orthop Clin North Am 2009; 40: 21-36
• 16 Panelos J, Voulgaris S, Michos E, Doukas M, Charalabopoulos K, Batistatou A. Chondrosarcoma of the spine: A rare case with unusual presentation. Diagn Pathol 2006; 30: 39
• 17 Bergh P, Gunterberg B, Meis-Kindblom JM, Kindblom LG. Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas: A center-based study of 69 cases. Cancer 2001; 91: 1201-12
• 18 Lloret I, Server A, Bjerkehagen B. Primary spinal chondrosarcoma: Radiologic findings with pathologic correlation. Acta Radiol 2006; 47: 77-84
• 19 Matsuda Y, Sakayama K, Sugawara Y, Miyawaki J, Kidani T, Miyazaki T. et al. Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: Case report. Spine 2006; 31: E231-6
• 20 Marmor E, Rhines LD, Weinberg JS, Gokaslan ZL. Total en bloc lumbar spondylectomy. Case report. J Neurosurg 2001; 95 Suppl (02) 264-9
• 21 Li YH, Yao XH. Primary intradural mesenchymal chondrosarcoma of the spine in a child. Pediatr Radiol 2007; 37: 1155-8
• 22 Boriani S, De Lure F, Bandiera S, Campanacci L, Biagini R, Di Fiore M. et al. Chondrosarcoma of the mobile spine: Report on 22 cases. Spine (Phila Pa 1976) 2000; 25: 804-12
• 23 Baratti D, Gronchi A, Pennacchioli E, Lozza L, Colecchia M, Fiore M. Chordoma: Natural history and results in 28 patients treated at a single institution. Ann Surg Oncol 2003; 10: 291-6
• 24 Boriani S, Bandiera S, Biagini R, Bacchini P, Boriani L, Cappuccio M. Chordoma of the mobile spine: Fifty years of experience. Spine 2006; 15 (31) 493-503
• 25 Molina C, Sciubba D, Gokaslan Z, Chou D, Wolinsky JP, Witham T. et al. En bloc resection of cervical chordomas: Comparing outcomes to tumor position. Spine J 2011; 11: S152
• 26 Barrenechea IJ, Perin NI, Triana A, Lesser J, Costantino P, Sen C. Surgical management of chordomas of the cervical spine. J Neurosurg Spine 2007; 6: 398-406
• 27 Hsieh PC, Gallia GL, Sciubba DM, Bydon A, Marco RA, Rhines L. et al. En bloc excisions of chordomas in the cervical spine: Review of five consecutive cases with more than 4-year follow-up. Spine (Phila Pa 1976) 2011; 36: E1581-7
• 28 Jallo J, Nathan D, Bierbrauer K, Farber E. Chordoma: A case report. Surg Neurol 1997; 48: 46-8
• 29 Hatem MA. Lumbar spine chordoma. Radiol Case Rep 2015; 9: 940
• 30 Jiang L, Liu ZJ, Liu XG, Ma QJ, Wei F, Lv Y. et al. Upper cervical spine chordoma of C2-C3. Eur Spine J 2009; 18: 293-8
• 31 Pham M, Awad M. Outcomes following surgical management of cervical chordoma: A review of published case reports and case series. Asian J Neurosurg 2017; 12: 389-97
• 32 Bartanusz V, Porchet F. Current strageties in the management of spinal metastatic disease. Swiss Surg 2003; 9: 55-62
• 33 Rayan F, Mukundan C, Shukla DD, Barrington RL. Odontoid metastasis: A potential lethal complication. J Orthop Traumatol 2009; 10: 199-201
• 34 Gill M, Swamy MN, Maheshwari V, Lingaraju TS, Mukherjee A. Spastic quadriparesis due to pathological fracture of odontoid secondary to carcinoma prostate: A rare presentation. J Craniovertebr Junction Spine 2017; 8: 153-5
• 35 Sarpel S, Sarpel G, Yu E, Hyder S, Kaufman B, Hindo W. et al. Early diagnosis of spinal-epidural metastasis by magnetic resonance imaging. Cancer 1987; 59: 1112-6
• 36 Bilsky MH, Shannon FJ, Sheppard S, Prabhu V, Boland PJ. Diagnosis and management of a metastatic tumor in the atlantoaxial spine. Spine (Phila Pa 1976) 2002; 27: 1062-9
• 37 Fung KY, Law SW. Management of malignant atlanto-axial tumours. J Orthop Surg (Hong Kong) 2005; 13: 232-9
• 38 Nair AP, Kumar R, Srivastav AK, Sahu RN, Kumar B. Outcome of dorsolumbar vertebral hemangiomas presenting with neuraxial compression. Indian J Orthop 2012; 46: 536-41
• 39 Ciftdemir M, Kaya M, Selcuk E, Yalniz E. Tumors of the spine. World J Orthop 2016; 7: 109-16
• 40 Puccioni MJ, Hellbusch LC. Displaced fracture in a hemangiomatous odontoid. J Spinal Disord 1997; 10: 445-7
• 41 Barzin M, Maleki I. Incidence of vertebral hemangioma on spinal magnetic resonance imaging in Northern Iran. Pak J Biol Sci 2009; 12: 542-4
• 42 Dang L, Liu C, Yang SM, Jiang L, Liu ZJ, Liu XG. et al. Aggressive vertebral hemangioma of the thoracic spine without typical radiological appearance. Eur Spine J 2012; 21: 1994-9
• 43 Nguyen JP, Djindjian M, Gaston A, Gherardi R, Benhaiem N, Caron JP. et al. Vertebral hemangiomas presenting with neurologic symptoms. Surg Neurol 1987; 27: 391-7
• 44 Tafti D, Cecava ND. Spinal Hemangioma. [Updated 2020 Jan 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Available from: https://www.ncbi.nlm.nih.gov/books/NBK532997?/
• 45 Jayakumar PN, Vasudev MK, Srikanth SG. Symptomatic vertebral haemangioma: Endovascular treatment of 12 patients. Spinal Cord 1997; 35: 624-8
• 46 Hao J, Hu Z. Percutaneous cement vertebroplasty in the treatment of symptomatic vertebral hemangiomas. Pain Physician 2012; 15: 43-9
• 47 Hay MC, Paterson D, Taylor TK. Aneurysmal bone cysts of the spine. J Bone Joint Surg Br 1978; 60: 406-11
• 48 Zileli M, Isik HS, Ogut FE, Is M, Cagli S, Calli C. Aneurysmal bone cysts of the spine. Eur Spine J 2013; 22: 593-601
• 49 Andersen BJ, Goldhagen P, Cahill DW. Aneurysmal bone cyst of the odontoid process: Case report. Neurosurgery 1991; 28: 592-4
• 50 Shkarubo AN, Kuleshov AA, Chernov IV, Vetrile MS, Berchenko GN, Lisyanskiy IN. et al. [Anterior stabilization of the CI-CIII vertebrae after transoral removal of an aggressive aneurysmal bone cyst of the CII vertebra (a case report and literature review)]. Zh Vopr Neirokhir Im N N Burdenko 2018; 82: 111-8
• 51 Chan MS, Wong YC, Yuen MK, Lam D. Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings. Pediatr Radiol 2002; 32: 601-4
• 52 Blake MA. Imaging in Oncology. Springer Verlag; 2008. ISBN: 0387755861
• 53 Saccomanni R. Aneurysmal bone cyst of spine: A review of literature. Arch Orthop Trauma Surg 2008; 128: 1145-7
• 54 Papagelopoulos PJ, Currier BL, Shaughnessy WJ, Sim FH, Ebsersold MJ, Bond JR. et al. Aneurysmal bone cyst of the spine. Management and outcome. Spine (Phila Pa 1976). 1998; 23: 621-8
• 55 Boriani S, De Iure F, Campanacci L, Gasbarrini A, Bandiera S, Biagini R. et al. Aneurysmal bone cyst of the mobile spine: report on 41 cases. Spine (Phila Pa 1976) 2001; 26: 27-35

Publication History

Received: 13 May 2020

Accepted: 31 August 2020

Article published online:
14 July 2021