Platelets in cancer and thrombosis

J. Riedl; I. Pabinger; C. Ay

doi:10.5482/HAMO-13-10-0054

Hämostaseologie, Table of Contents

Hamostaseologie 2014; 34(01): 54-62
DOI: 10.5482/HAMO-13-10-0054

Review

Schattauer GmbH

Platelets in cancer and thrombosis

Die Rolle der Thrombozyten bei Krebs und Thrombose

J. Riedl

¹Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Austria

,

I. Pabinger

¹Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Austria

,

C. Ay

¹Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Austria

› Author Affiliations

Abstract

Summary

Platelets are the smallest circulating blood cells and their major function is the maintenance of haemostasis. They do not have a nucleus, but instead a multitude of granules that contain molecules important for several physiological processes. These granules can be released after platelet activation and thereby platelets take part in haemostasis, wound repair or immunological processes. Furthermore, platelets are also involved in the pathophysiology of several diseases, including cancer. Platelets can support various steps of cancer development and progression by promoting tumour growth, angiogenesis and metastasis. Moreover, platelets contribute to the hypercoagulable state frequently observed in cancer patients, leading to an increased risk of venous thromboembolism (VTE). In previous studies a high platelet count was repeatedly found to be associated with an elevated risk of VTE and a worse prognosis in patients with cancer.

The aim of this review is to give an overview of the most important alterations of platelet physiology in cancer patients and how these alterations may influence cancer disease and contribute to cancer-associated VTE.

Zusammenfassung

Thrombozyten sind die kleinsten zirkulierenden Blutzellen und stellen den zellulären Part des Blutgerinnungssystems dar. Sie enthalten keinen Zellkern, dafür jedoch eine Menge gerinnungsaktiver, angiogenetischer und immunwirksamer Substanzen, die sie bei Aktivierung ausschütten können. Dadurch sind sie neben der Blutgerinnung auch in verschiedenste andere physiologische Prozesse wie Wundheilung oder Immunabwehr eingebunden. Thrombozyten spielen jedoch auch in der Pathophysiologie von Krebserkrankungen eine Rolle. Sie können das Tumorwachstum, Gefäßneubildung und die Metastasierung fördern, zudem sind sie an der Entstehung eines prokoagulatorischen Zustandes beteiligt, der bei Krebspatienten oft beobachtet wird und zu einer erhöhten Thromboseneigung führt. In bisherigen Studien waren hohe Thrombozytenzahlen mit einer schlechten Prognose und einem erhöhten Risiko für venöse Thromboembolien (VTE) bei Krebspatienten assoziiert.

Dieses Review soll einen Überblick über die wichtigsten Veränderungen und Eigenschaften von Thrombozyten im Rahmen von Krebserkrankungen geben, sowie deren Einfluss auf die Entstehung einer krebs-assoziierten VTE beleuchten.

Keywords

Platelets - cancer - venous thromboembolism

Schlüsselwörter

Thrombozyten - Krebs - venöse - Thrombo- embolie

Full Text

References

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