DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 05 · Volume 122 · May 2022 DOI: 10.1055/s-012-53835

Invited Editorial Focus

657
López-Gálvez, Raquel; Rivera-Caravaca, José Miguel: Growth Differentiation Factor 15 in Cardiovascular Diseases: Predicting Bleeding after Cardiac Surgery and Beyond That!

T&H Insights

661
Jurk, Kerstin: Functional Diversity of Primed Platelets—Powered by Machine Learning

Invited Mini Series: Novel Clinical Concepts in Thrombosis

662
Wiredu, Courteney; Haynes, Norrisa; Guerra, Carmen; Ky, Bonnie: Racial and Ethnic Disparities in Cancer-Associated Thrombosis
Supplementary Material

Review Article

666
Mbiandjeu, Serge; Balduini, Alessandra; Malara, Alessandro: Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and Diseases

Coagulation and Fibrinolysis

679
Lu, Yeling; Villoutreix, Bruno O.; Biswas, Indranil; Ding, Qiulan; Wang, Xuefeng; Rezaie, Alireza R.: Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia
692
Holstein, Katharina; Witt, Leonora; Matysiak, Anna; Schmidt, Constantin; Barvencik, Florian; Amling, Michael; Rolvien, Tim; Langer, Florian: The Bone Microarchitecture Deficit in Patients with Hemophilia Is Influenced by Arthropathy, Hepatitis C Infection, and Physical Activity
Supplementary Material
703
Kazem, Niema; Hammer, Andreas; Koller, Lorenz; Hofer, Felix; Steinlechner, Barbara; Laufer, Günther; Hengstenberg, Christian; Wojta, Johann; Sulzgruber, Patrick; Niessner, Alexander: The Prognostic Potential of Growth Differentiation Factor-15 on Bleeding Events and Patient Outcome after Cardiac Surgery—A Prospective Cohort Study
Supplementary Material
715
Lunghi, Barbara; Morfini, Massimo; Martinelli, Nicola; Balestra, Dario; Linari, Silvia; Frusconi, Sabrina; Branchini, Alessio; Cervellera, Christian F.; Marchetti, Giovanna; Castaman, Giancarlo; Bernardi, Francesco: The Asialoglycoprotein Receptor Minor Subunit Gene Contributes to Pharmacokinetics of Factor VIII Concentrates in Hemophilia A
Supplementary Material

Cellular Haemostasis and Platelets

726
Veninga, Alicia; Baaten, Constance C. F. M. J.; De Simone, Ilaria; Tullemans, Bibian M. E.; Kuijpers, Marijke J. E.; Heemskerk, Johan W. M.; van der Meijden, Paola E. J.: Effects of Platelet Agonists and Priming on the Formation of Platelet Populations
Supplementary Material
739
Li, Weiqi; Ma, Yongjie; Zhang, Chunmei; Chen, Binlin; Zhang, Xiandan; Yu, Xin; Shuai, Hongyan; He, Qilian; Ya, Fuli: Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth
Supplementary Material
755
Wang, Yun; Mao, Jianhua; Li, Li; Xiao, Bing; Ruan, Zheng; Liu, Yichen; Zhang, Guowei; Wang, Dawei; Mi, Jian-Qing; Fang, Chao; Xi, Xiaodong; Shi, Xiaofeng; Wang, Jin: Characteristics of the Thrombus Formation in Transgenic Mice with Platelet-Targeted Factor VIII Expression
Supplementary Material
767
Janus-Bell, Emily; Yakusheva, Alexandra; Scandola, Cyril; Receveur, Nicolas; Ahmed, Usman Muhammad; Mouriaux, Clarisse; Bourdon, Catherine; Loubière, Cécile; Eckly, Anita; Senis, Yotis A.; Panteleev, Mikhail A.; Gachet, Christian; Mangin, Pierre H.: Characterization of the Role of Integrin α5β1 in Platelet Function, Hemostasis, and Experimental Thrombosis
Supplementary Material

Endothelium and Angiogenesis

777
Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng: KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression
Supplementary Material

Stroke, Systemic or Venous Thromboembolism

789
Valerio, Luca; Fedeli, Ugo; Schievano, Elena; Avossa, Francesco; Barco, Stefano: Decline in Overall Pulmonary Embolism-Related Mortality and Increasing Prevalence of Cancer-Associated Events in the Veneto Region (Italy), 2008–2019
796
Agnelli, Giancarlo; Muñoz, Andrés; Franco, Laura; Mahé, Isabelle; Brenner, Benjamin; Connors, Jean M.; Gussoni, Gualberto; Hamulyak, Eva N.; Lambert, Catherine; Suero, Maria Rosales; Bauersachs, Rupert; Torbicki, Adam; Becattini, Cecilia: Apixaban and Dalteparin for the Treatment of Venous Thromboembolism in Patients with Different Sites of Cancer
Supplementary Material
808
Sharman Moser, Sarah; Chodick, Gabriel; Ni, Yan G.; Chalothorn, Dan; Wang, Ming-Dauh; Shuldiner, Alan R.; Morton, Lori; Salomon, Ophira; Jalbert, Jessica J.: The Association between Factor XI Deficiency and the Risk of Bleeding, Cardiovascular, and Venous Thromboembolic Events
Supplementary Material
818
de Winter, Maria A.; Dorresteijn, Jannick A. N.; Ageno, Walter; Ay, Cihan; Beyer-Westendorf, Jan; Coppens, Michiel; Klok, Frederikus A.; Moustafa, Farès; Riva, Nicoletta; Ruiz Artacho, Pedro C.; Vanassche, Thomas; Nijkeuter, Mathilde: Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score
Supplementary Material
830
Wang, Tzu-Fei; Carrier, Marc; Fournier, Karine; Siegal, Deborah M.; Le Gal, Grégoire; Delluc, Aurélien: Oral Anticoagulant Use in Patients with Morbid Obesity: A Systematic Review and Meta-Analysis
Supplementary Material

Atherosclerosis and Ischaemic Disease

842
Zhang, Yunnan; Zhang, Yi; Shi, Xiujin; Lin, Baidi; Han, Jialun; Wang, Yifan; Yan, Jialin; Peng, Wenxing; Li, Wenzheng; Zheng, Ze; Lin, Yang: Clopidogrel versus Ticagrelor in CYP2C19 Loss-of-Function Allele Noncarriers: A Real-World Study in China

Letter to the Editor

853
Busnelli, Marco; Manzini, Stefano; Colombo, Alice; Bonacina, Fabrizia; Norata, Giuseppe D.; Franchi, Elsa; Castiglioni, Silvia; Andronis, Christos; Lekka, Eftychia; Scanziani, Eugenio; Chiesa, Giulia: Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment
Supplementary Material

Trial Protocol Design Paper

857
Sanchez, Olivier; Charles-Nelson, Anaïs; Ageno, Walter; Barco, Stefano; Binder, Harald; Chatellier, Gilles; Duerschmied, Daniel; Empen, Klaus; Ferreira, Melanie; Girard, Philippe; Huisman, Menno V.; Jiménez, David; Katsahian, Sandrine; Kozak, Matija; Lankeit, Mareike; Meneveau, Nicolas; Pruszczyk, Piotr; Petris, Antoniu; Righini, Marc; Rosenkranz, Stephan; Schellong, Sebastian; Stefanovic, Branislav; Verhamme, Peter; de Wit, Kerstin; Vicaut, Eric; Zirlik, Andreas; Konstantinides, Stavros V.; Meyer, Guy; for the PEITHO-3 Investigators: Reduced-Dose Intravenous Thrombolysis for Acute Intermediate–High-risk Pulmonary Embolism: Rationale and Design of the Pulmonary Embolism International THrOmbolysis (PEITHO)-3 trial