Berlin, im Februar 2021 – COVID-19-Schutzimpfung von Schwangeren und Frauen mit Kinderwunsch

Die Stellungnahmen zur COVID-19-Schutzimpfung für Schwangere und Frauen mit Kinderwunsch basieren auf einem sorgfältig abgestimmten ExpertInnenkonsens und können sich – insofern neue Erkenntnisse veröffentlicht werden – zeitnah ändern. Die Verantwortung für das konkrete Vorgehen bleibt bei dem vor Ort medizinisch betreuenden Team, dessen Entscheidungen durch die Empfehlung unterstützt werden sollen.

Publication History

Article published online:
14 April 2021

• Literatur

• 1 EMA. Treatments and vaccines for COVID-19 2020. Online (Stand: 14.01.2021): https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines-covid-19%23post-authorisation-section
• 2 RKI, STIKO. Mitteilung der Ständigen Impfkommission am Robert Koch-Institut: Beschluss der STIKO zur 1. Aktualisierung der COVID-19-Impfempfehlung und die dazugehörige wissenschaftliche Begründung, STIKO-Empfehlung zur COVID-19-Impfung Aktualisierung am 8. Januar 2021. 2021 Online (Stand: 09.01.2021): https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2021/Ausgaben/02_21.pdf?__blob=publicationFile
• 3 EMA. Human medicine European public assessment report (EPAR): Comirnaty 2020. Online (Stand: 14.01.2021): https://www.ema.europa.eu/en/medicines/human/summaries-opinion/comirnaty
• 4 WHO, Strategic Advisory Group of Experts on Immunization (SAGE). Interim recommendations for use of the Moderna mRNA-1273 vaccine against COVID-19 2021. [updated 25.01.2021]. Online (Stand: 28.01.2021): https://www.who.int/publications/i/item/interim-recommendations-for-use-of-the-moderna-mrna-1273-vaccine-against-covid-19
• 5 JCVI. Advice on priority groups for covid 19 vaccination 30 dec 2020 revised 2020. Online (Stand: 09.01.2021): https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/950113/jcvi-advice-on-priority-groups-for-covid-19-vaccination-30-dec-2020-revised.pdf
• 6 ACOG. Vaccinating pregnant and lactating patients against covid-19 2020. Online (Stand: 09.01.2021): https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/vaccinating-pregnant-and-lactating-patients-against-covid-19
• 7 RCOG. Covid-19 vaccination and pregnancy 2020. Online (Stand: 09.01.2021): https://www.rcog.org.uk/en/guidelines-research-services/guidelines/coronavirus-pregnancy/covid-19-virus-infection-and-pregnancy%23vaccines
• 8 ESHRE COVID-19 Working Group. COVID-19 vaccination and assisted reproduction – Statement from the ESHRE COVID-19 Working Group 2021 [Date of publication: 12 January 2021 Last update: 12 January]. Online (Stand: 14.01.2021): https://www.eshre.eu/Press-Room/ESHRE-News
• 9 Allotey J, Stallings E, Bonet M. et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320
• 10 Khoury R, Bernstein PS, Debolt C. et al. Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers. Obstet Gynecol 2020; 136: 273-282
• 11 Cohen J, Vignaux O, Jacquemard F. Covid-19 in pregnant women: General data from a French National Survey. Eur J Obstet Gynecol Reprod Biol 2020; 251: 267-268
• 12 Kayem G, Lecarpentier E, Deruelle P. et al. A snapshot of the Covid-19 pandemic among pregnant women in France. J Gynecol Obstet Hum Reprod 2020; 49: 101826
• 13 Molteni E, Astley CM, Ma W. et al. SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology. medRxiv 2020;
• 14 Khalil A, Kalafat E, Benlioglu C. et al. SARS-CoV-2 infection in pregnancy: A systematic review and meta-analysis of clinical features and pregnancy outcomes. EClinicalMedicine 2020; 25: 100446
• 15 Antoun L, Taweel NE, Ahmed I. et al. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol 2020; 252: 559-562
• 16 Diriba K, Awulachew E, Getu E. The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal-fetal transmission: a systematic review and meta-analysis. Eur J Med Res 2020; 25: 39
• 17 Ahlberg M, Neovius M, Saltvedt S. et al. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. JAMA 2020; 324: 1782-1785
• 18 Jering KS, Claggett BL, Cunningham JW. et al. Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19. JAMA Intern Med 2021;
• 19 Pulinx B, Kieffer D, Michiels I. et al. Vertical transmission of SARS-CoV-2 infection and preterm birth. Eur J Clin Microbiol Infect Dis 2020; 39: 2441-2445
• 20 Sisman J, Jaleel MA, Moreno W. et al. Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant. Pediatr Infect Dis J 2020; 39: e265-e267
• 21 Deniz M, Tezer H. Vertical transmission of SARS CoV-2: a systematic review. J Matern Fetal Neonatal Med 2020;
• 22 Walker KF, OʼDonoghue K, Grace N. et al. Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG 2020; 127: 1324-1336
• 23 Kubiak JM, Yee J, Cagino K. et al. SARS-CoV-2 serology levels in pregnant women and their neonates. Am J Obstet Gynecol 2021;
• 24 Lebrao CW, Cruz MN, Silva MHD. et al. Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection. J Hum Lact 2020; 36: 609-613
• 25 Gao X, Wang S, Zeng W. et al. Clinical and immunologic features among COVID-19-affected mother-infant pairs: antibodies to SARS-CoV-2 detected in breast milk. New Microbes New Infect 2020; 37: 100752
• 26 Lackey KA, Pace RM, Williams JE. et al. SARS-CoV-2 and human milk: What is the evidence?. Matern Child Nutr 2020; 16: e13032
• 27 Cimolai N. Applying Immune Instincts and Maternal Intelligence from Comparative Microbiology to COVID-19. SN Compr Clin Med 2020;
• 28 Moderna. COVID-19 Vaccine VRBPAC Briefing Document. Online (Stand: 09.01.2021): https://www.fda.gov/media/144434/download
• 29 ACOG Practice Advisory. Vaccinating Pregnant and Lactating Patients Against COVID-19 (Last updated March 4, 2021). Online (Stand: 11.03.2021): https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/vaccinating-pregnant-and-lactating-patients-against-covid-19
• 30 CDC. Advisory Committee on Immunization Practices (ACIP) COVID-19 vaccine safety update, March 1, 2021. Online (Stand: 11.03.2021): https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-02/28-03-01/05-covid-Shimabukuro.pdf
• 31 Bahl K, Senn JJ, Yuzhakov O. et al. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses. Mol Ther 2017; 25: 1316-1327
• 32 Pardi N, Tuyishime S, Muramatsu H. et al. Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes. J Control Release 2015; 217: 345-351
• 33 CDC. Pregnancy or breastfeeding – vaccines reccomendations 2020. Online (Stand: 09.01.2021): https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html
• 34 Cimolai N. A Minimalist Strategy Towards Temporarily Defining Protection for COVID-19. SN Compr Clin Med 2020;
• 35 ASRM American Society for Reproductive Medicine. PATIENT MANAGEMENT AND CLINICAL RECOMMENDATIONS DURING THE CORONAVIRUS (COVID-19) PANDEMIC, UPDATE No. 11 – COVID-19 Vaccination 2020. [updated 16.12.2020]. Online (Stand: 17.01.2021): https://www.asrm.org/globalassets/asrm/asrm-content/news-and-publications/covid-19/covidtaskforceupdate11.pdf
• 36 Voysey M, Clemens SAC, Madhi SA. et al. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 2021; 397: 99-111
• 37 EMA. COVID-19 Vaccine AstraZeneca: Product Information as approved by the CHMP on 29 January 2021, pending endorsement by the European Commission 2021. [updated 29.01.2021]. Online (Stand: 02.02.2021): https://www.ema.europa.eu/en/documents/product-information/covid-19-vaccine-astrazeneca-product-information-approved-chmp-29-january-2021-pending-endorsement_en.pdf
• 38 RCOG. Updated advice on COVID-19 vaccination in pregnancy and women who are breastfeeding 2020. Online (Stand: 02.02.2021): https://www.rcog.org.uk/en/news/updated-advice-on-covid-19-vaccination-in-pregnancy-and-women-who-are-breastfeeding/
• 39 RKI, STIKO. Beschluss der STIKO zur 2. Aktualisierung der COVID-19-Impfempfehlung und die dazugehörige wissenschaftliche Begründung 2021. [updated 29.01.2021]. Online (Stand: 02.02.2021): https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2021/Ausgaben/05_21.pdf?__blob=publicationFile