Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[b,f][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds

Abstract

An FeCl₃-catalyzed Povarov reaction for the efficient synthesis of dibenzo[b,f][1,7]naphthyridines utilizing 1-(2-alkynylaryl)-2-pyrrolecarbaldehydes and arylamines in excellent yields is demonstrated. The essential features of the present strategy are easy preparation of substrates, broad substrate scope, mild reaction conditions, and high atom economy and yields, in the presence of environmentally friendly iron catalysis.

Key words

arylpyrrolecarbaldehydes - phosphorus oxychloride - arylamines - 1,7-naphthyridines - ferric chloride

Publication History

Received: 11 May 2024

Accepted after revision: 20 June 2024

Accepted Manuscript online:
20 June 2024

Article published online:
15 July 2024

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