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Synthesis 2026; 58(02): 204-212
DOI: 10.1055/a-2722-9900
DOI: 10.1055/a-2722-9900
Paper
Iron-Catalyzed One-Pot Four-Component Synthesis of Dihydropyridinones from Benzyl Alcohols and Ketones
Autor*innen
Abstract
An efficient, facile, and one-pot four-component methodology for the cyclization of readily available benzyl alcohols, acetophenones, Meldrum’s acid, and NH4OAc to access dihydropyridinones (valuable scaffolds in medicinal and synthetic organic chemistry) was established. This four-component cyclization reaction supports the straightforward manufacture of several dihydropyridinones. Several C–C and C–N bonds were constructs to synthesize the desired product. Readily available starting materials, operational simplicity, good to excellent reaction yields, and tolerance of various functional groups are the interesting features of this protocol.
Keywords
Benzyl alcohols - Meldrum’s acid - Dehydrogenation - Knölker catalysts - DihydropyridinonesPublikationsverlauf
Eingereicht: 03. Oktober 2025
Angenommen: 14. Oktober 2025
Accepted Manuscript online:
14. Oktober 2025
Artikel online veröffentlicht:
12. November 2025
© 2025. Thieme. All rights reserved.
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