EDNET – Forschungsverbund zur Psychotherapie von Essstörungen

Zusammenfassung

Der Artikel gibt einen Überblick über die Organisation, die 4 randomisiert-kontrollierten multizentrischen Psychotherapiestudien und die assoziierten Studien des Forschungsverbundes zur Psychotherapie der Essstörungen (EDNET). Die multizentrischen Studien beinhaltet eine ambulante Psychotherapiestudie (psychodynamische Fokaltherapie, kognitiv-behaviorale Therapie und „treatment as usual”) für erwachsene Pa-tientinnen mit AN, eine Studie zum Vergleich eines stationären und eines tagesklinischen Settings bei adoleszenter AN und zwei Internet-gestützte Rückfallprophylaxestudien nach stationärer Therapie bei Patientinnen mit AN und mit BN. Vernetzt mit den Psychotherapiestudien werden Studien zur Neuropsychologie, strukturellen und funktionellen Bildgebung, Genetik, Endokrinologie sowie Detailanalysen zu Mediatoren und Moderatoren im psychotherapeutischen Prozess durchgeführt.

Abstract

The paper gives an overview of the 4 randomized-controlled multi-center psychotherapy studies and the associated studies of the Eating Disorders Diagnostic and Treatment Network (EDNET). The multi-center trials include an outpatient treatment trial for AN comparing focal psychodynamic psychotherapy, cognitive-behavioral therapy, and treatment as usual, a trial comparing in- and day-patient treatment in adolescents with AN, and two internet-based relapse prevention trials for patients with AN and with BN after discharge from inpatient treatment. Associated studies are grouped around these core proposals covering neuropsychology, structural as well as functional neuroimaging, genetics, endocrinology, and moderators and mediators of treatment outcome.

Schlüsselwörter

Psychotherapie - Essstörungen - randomisiert-kontrollierte Studien - multizentrisch - Internet

Key words

psychotherapy - eating disorders - randomized-controlled studies - multi-center - internet

Literatur

• 1 Hudson JI, Hiripi E, Pope HG. et al . The prevalence and correlates of eating disorders in the National Comorbidity Survey replication.  Biol Psychiatry. 2007;  61 348-358
• 2 Agras WS, Brandt HA, Bulik CM. et al . Report of the National Institutes of Health Workshop on Overcoming Barriers to Treatment Research in Anorexia Nervosa.  Int J Eat Disord. 2004;  35 509-521
• 3 Hay P, Bacaltchuk J, Claudino A. et al .Individual psychotherapy in the outpatient treatment of adults with anorexia nervosa. Cochrane Database Syst Rev 2004
• 4 Löwe B, Zipfel S, Buchholz C. et al . Long-term outcome of anorexia nervosa in a prospective 21-year follow-up study.  Psychol Med. 2001;  31 881-890
• 5 Zipfel S, Löwe B, Reas DL. et al . Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study.  Lancet. 2000;  355 721-722
• 6 Nielsen S, Moller-Madsen S, Isager T. et al . Standardized mortality in eating disorders – a quantitative summary of previously published and new evidence.  J Psychosom Res. 1998;  4 413-434
• 7 Herzog W, Deter HC, Fiehn W. et al . Medical findings and predictors of long-term physical outcome in anorexia nervosa: a prospective, 12-year follow-up study.  Psychol Med. 1997;  27 269-279
• 8 Herzog W, Schellberg D, Deter HC. First recovery in anorexia nervosa patients in the long-term course: a discrete-time survival analysis.  J Consult Clin Psychol. 1997;  65 169-177
• 9 Fichter MM, Quadflieg N, Hedlund S. Twelve-year course and outcome predictors of anoexia nervosa.  Int J Eat Disord. 2006;  39 87-100
• 10 Steinhausen HC. The outcome of anorexia nervosa in the 20th century.  Am J Psychiatry. 2002;  159 1284-1293
• 11 Steinhausen HC. Outcome of eating disorders.  Child Adolesc Psychiatr Clin North Am. 2009;  18 225-242
• 12 National Institute for Clinical Excellence (“NICE”) . Eating Diorders: Core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. http://www.nice.org.uk 2004; 
• 13 le Grange D, Lock J. The dearth of psychological treatment studies for anorexia nervosa.  Int J Eat Disord. 2005;  37 79-91
• 14 Woodside DB. Treatment of anorexia nervosa: more questions than answers.  Int J Eat Disord. 2005;  37 S41-S42
• 15 Bulik CM, Berkman ND, Brownley KA. et al . Anorexia nervosa treatment: A systematic review of randomized controled trials.  Int J Eat Disord. 2007;  40 310-320
• 16 Dare C, Eisler I, Russell G. et al . Psychological therapies for adults with anorexia nervosa: randomised controlled trial of out-patient treatments.  Br J Psychiatry. 2001;  178 216-221
• 17 McIntosh VV, Jordan J, Carter FA. et al . Three psychotherapies for anorexia nervosa: a randomized, controlled trial.  Am J Psychiatry. 2005;  162 741-747
• 18 Bergh C, Brodin U, Lindberg G. et al . Randomized controlled trial of a treatment for anorexia and bulimia nervosa.  Proc Natl Acad Sci. 2002;  99 9486-9491
• 19 Halmi KA, Agras WS, Crow S. et al . Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designs.  Arch Gen Psychiatry. 2005;  62 776-781
• 20 Wild B, Friederich HC, Gross G. et al . The ANTOP study: focal psychodynamic psychotherapy, cognitive-behavioral therapy, and treatment as usual in outpatients with anorexia nervosa – a randomized controlled trial.  , In Revision.
• 21 Fairburn CG, Cooper Z, Shafran R. Cognitive behaviour therapy for eating disorders: a “transdiagnostic” theory and treatment.  Behav Res Ther. 2003;  41 509-528
• 22 Fairburn CG. Cognitive behavior therapy and eating disorders. New York: Guilford Press 2008
• 23 Dare C, Crowther C. Living dangerously: psychoanalytic psychotherapy of anorexia nervosa. In G. Szmukler, C. Dare, J. Treasure, (Eds) Handbook of Eating Disorders: Theory, Treatment and Research. John Wiley & Sons 1995: 293
• 24 Schauenburg H, Friederich HC, Wild B. et al .Fokale Psychodynamische Psychotherapie (FPT) der Anorexia nervosa – ein Behandlungsmanual. Zur Publikation eingereicht 2000
• 25 Gowers SG, Weetman J, Shore A. et al . Impact of hospitalisation on the outcome of adolescent anorexia nervosa.  Br J Psychiatry. 2000;  176 138-141
• 26 Gowers SG, Clark A, Roberts C. et al . Clinical effectiveness of treat-ments for anorexia nervosa in adolescents.  Br J Psychiatry. 2007;  91 427-435
• 27 Herpertz-Dahlmann B, Salbach-Andrae H. Overview of treatment modalities in adolescent anorexia nervosa.  Child Adolesc Psychiatr Clin N Am. 2009;  18 131-145
• 28 Arbeitskreis OPD. Operationalisierte Psychodynamische Diagnostik OPD-2. Bern: Huber
• 29 Kaplan AS, Walsh BT, Olmsted M. et al . The slippery slope: prediction of successful weight maintenance in anorexia nervosa.  Psychol Med. 2008;  10 1-9 , [Epub ahead of print]
• 30 Pike KM, Walsh BT, Vitousek K. et al . Cognitive behaviour therapy in the posthospitalization treatment of anorexia nervosa.  Am J Psychiatry. 2003;  160 2046-2049
• 31 Cooper PJ, Coker S, Fleming C. An evaluation of the efficacy of supervised cognitive behavioral self help for bulimia nervosa.  J Psychosom Res. 1996;  40 281-287
• 32 Fairburn CG. Overcoming Binge Eating. A new scientifically based program. New York: Guilford Press 1995
• 33 Schmidt U, Treasure J. Getting Better Bit[e] by Bit[e]. A Survival Kit for Sufferers of Bulimia nervosa and Binge Eating Disorders. London: Lawrence Erlbaum 1993
• 34 Treasure J. Anorexia nervosa. A Survival Guide for Families, Friends and Sufferers. Psychology Press Ltd. 1997
• 35 Halmi KA, Agras WS, Mitchell J. et al . Relapse predictors of patients with bulimia nervosa who achieved abstinence through cognitive behavioral therapy.  Arch Gen Psychiatry. 2002;  59 1105-1109
• 36 Mitchell JE, Agras WS, Wilson GT. et al . A trial of a relapse prevention strategy in women with bulimia nervosa who respond to cognitive-behavior therapy.  Int J Eat Disord. 2004;  35 549-555
• 37 Bara-Carril N, Williams CJ, Pombo-Carril MG. et al . Preliminary investigation into the feasibility and efficacy of a CD-ROM-based cognitive-behavioural self-help intervention for bulimia nervosa.  Int J Eat Disord. 2004;  35 538-548
• 38 Stice E, Shaw H. Eating disorder prevention programs: a meta-analytic review.  Psychol Bull. 2004;  130 206-227
• 39 Jacobi C, Morris L, Beckers C. Maintenance of internet-based prevention: A randomized controlled trail.  Int J Eat Disord. 2007;  40 114-119
• 40 Jacobi C, Morris L, Beckers C. Reduktion von Risikofaktoren für gestörtes Essverhalten: Adaptation und erste Ergebnisse eines Internet-gestützten Präventionsprogramms.  Zeitschrift für Gesundheitspsychologie. 2005;  13 92-101
• 41 Beintner I, Jacobi C, Taylor CB. Reduktion von Risikofaktoren für Essstörungen: Wirksamkeit eines Internet-gestützen Präventionsprogramms in Deutschland und den USA.  , Wissenschaftlicher Vortrag auf dem 26 Symposium der Fachgruppe Klinische Psychologie und Psychotherapie der DGPs, 01.–03. Mai, 2008, Potsdam.
• 42 Hebebrand J. Diagnostic issues in eating disorders and obesity.  Child Adolesc Psychiatr Clin N Am.. 2009;  18 1-16
• 43 Frieling H, Gozner A, Römer KD. et al . Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders.  Neuropsychobiol. 2008;  58 48-52
• 44 Frieling H, Gozner A, Römer KD. et al . Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosa.  Mol Psychiatry. 2007;  12 229-230
• 45 Müller T, Föcker M, Holtkamp K. et al . Leptin-mediated neuroendocrine alterations in anorexia nervosa: somatic and behavioural implications.  Child Adolesc Psychiatr Clin N Am. 2009;  18 117-129
• 46 Hebebrand J, Muller TD, Holtkamp K. et al . The role of leptin in anorexia nervosa: clinical implications.  Mol Psychiatry. 2007;  12 23-35
• 47 Kraemer HC, Wilson GT, Fairburn CG. et al . Mediators and moderators of treatment effects in randomized clinical trials.  Arch Gen Psychiatry. 2002;  59 877-883
• 48 Wittchen HU, Zaudig M, Fydrich T. Strukturiertes Klinisches Interview für DSM-IV (SKID). Göttingen: Hogrefe 1997
• 49 Fichter M, Quadflieg N. SIAB-Ex. Strukturiertes Interview für anorektische und bulimische Essstörungen nach DSM-IV und ICD-10. Göttingen: Hogrefe 1999

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