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Thromb Haemost 1969; 22(03): 466-481
DOI: 10.1055/s-0038-1651384
Originalarbeiten-Original Articles-Travaux Originaux
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Platelet Reactions and Immune Processes

II. The Inhibition of Platelet Aggregation by Complement Inhibitors
F Jobin
1   Départment de biochimie, Faculté de Médecine, Université Laval and the Service d’Hématologie, Hôpital du Saint-Sacrement, Québec
,
F Tremblay
1   Départment de biochimie, Faculté de Médecine, Université Laval and the Service d’Hématologie, Hôpital du Saint-Sacrement, Québec
› Author AffiliationsSupported by grants from the Medical Research Council of Canada (MA-2342) and from Geigy Pharmaceutical Co. of Canada, Ltd.
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Publication Date:
10 June 2018 (online)

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Summary

We have studied the effect of complement inhibitors of various classes on platelet aggregation induced by collagen or by latex. The majority of the complement inhibitors which we studied inhibited collagen- or latex-induced platelet aggregation.

The possible role of complement as a mediator in the activation of platelet reactions is discussed.

These findings indicate that some chemicals are able to act on some of the immune reactions and also on platelet thrombogenetic reactions. It is suggested that drugs or combination of drugs having such a polyvalence might be of particular benefit in thrombo-immuno-inflammatory conditions.

 

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