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Thromb Haemost 1970; 24(01/02): 001-009
DOI: 10.1055/s-0038-1654204
Originalarbeiten – Original Articles – Travaux Originaux
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Studies on the Participation of Hageman Factor in Fibrinolysis[*]

R.P McDonagh Jr   **)
1   Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, N.C., 27514
,
J.H Ferguson
1   Department of Physiology, University of North Carolina School of Medicine, Chapel Hill, N.C., 27514
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

The specific inhibition of the kaolin-mediated Hageman factor activation by the polycations : lysozyme, spermine tetrahydrochloride, and cytochrome c was confirmed. These polycations were without any antiplasmin or antiplasminogen-activator activity when tested in a one-stage lysis system. However, marked inhibition of plasminogen-activator generation in normal plasma by these polycations was noted in the activator-generation test. The proposed role of Hageman factor as that of a lysokinase or indirect activator of plasminogen is supported by these experiments.

*) Supported by NIH Grant No HE 01510.


**) Trainee, NIH Cardiovascular Training Grant, No. HE 05486, awarded to the Department of Medicine, U .N. C. School of Medicine.


 

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