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Thromb Haemost 1970; 24(01/02): 214-223
DOI: 10.1055/s-0038-1654227
Originalarbeiten – Original Articles – Travaux Originaux
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The Adsorption of Coagulation Factors onto Phospholipids

Its Role in the Reaction Mechanism of Blood Coagulation
H. C Hemker
1   Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands
,
M. J. P Kahn   *
1   Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands
,
P. P Devilee
1   Laboratories of Coagulation Biochemistry and Cardiovascular Biochemical Research, Departments of Haematology and Cardiology, University Hospital, Leiden, The Netherlands
› Author Affiliations
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Publication History

Publication Date:
28 June 2018 (online)

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Summary

It is shown that factors VIII and IX react with phospholipid in a way fully analogous to the reaction of factors V and X. From this it is concluded that a complex of factors VIII and IX adsorbed onto a phospholipid micelle may be the entity that activates factor X in the intrinsic pathway. The implications of this finding for the concepts of the reaction mechanism of blood coagulation are discussed. It is shown that instead of the original 7-step cascade of Macfarlane, a 4-step cascade consisting partly of complex enzymes is more probable.

* Present address: Hôpital Universitaire St. Pierre, Service du Centre Albert Hustin, 322 Rue Haute, Bruxelles, Belgique.


 

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