On the Action Mechanism of Some Fibrinolysis Inhibitors

Summary

1. Both p-aminomethylcyclohexanecarboxylic acid (AMCA) and p-aminomethylbenzoic acid (PAMBA) exhibit a significant inhibiting activity on the fibrinolysis. The inhibition conldbe observed already at concentrations as low as 10^-4 M. The inhibition was higher in a system activated by urokinase than in a system activated by streptokinase. By comparing the same concentrations the greatest inhibitory activity was observed in AMCA, a lesser one in PAMBA, and the least one in EACA.

2. AMCA exhibited mostly an antiactivator effect; the inhibition of pi asm in was very weak.

3. Intravenous injections of either AMCA, in recommended therapeutic doses of 15-20 mg/kg body weight, or PAMBA, in recommended therapeutic doses of 1.5 mg/kg body weight, exhibited an inhibitive effect on the fibrinolysis in vivo. Their effects set on, on the average, inside 30-60 min, and lasted 2-6 hrs. Great individual variations were found. AMCA had the highest inhibitory effect.

4. AMCA inhibits not only the blood activator but also the tissue activator. AMCA possesses, apart from the antifibrinolytic and antifibrinogenolytic activity, also a significant antitryptic activity.

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