Download PDF
Thromb Haemost 1965; 13(01): 001-007
DOI: 10.1055/s-0038-1656281
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Biological Half-Time of Hageman Factor

J. J Veltkamp
1   Haematology Section of the Department of Internal Medicine, (Head: Prof. J. Mulder, M. D.), University Hospital, Leyden, The Netherlands
,
E. A Loeliger
1   Haematology Section of the Department of Internal Medicine, (Head: Prof. J. Mulder, M. D.), University Hospital, Leyden, The Netherlands
,
H. C Hemker
1   Haematology Section of the Department of Internal Medicine, (Head: Prof. J. Mulder, M. D.), University Hospital, Leyden, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2018 (online)

Also available at
    Permissions and Reprints

Summary

The biological half-time of factor XII was assessed (a) after transfusion of freshly-drawn, normal intact ACD-plasma into a patient having Hageman trait and suffering from polycythaemia vera, and (b) with blocked synthesis in a patient suffering from acute liver dystrophy due to phosphoric intoxication. The results obtained suggest that the biological half-time under normal conditions has a value between 50 and 70 hrs.

 

  • References

  • 1 Borchgrevink C. F, Egeberg O, Pool J. G, Skulason T, Storniorken H, Waaler B. A study of a case of congenital hypoprothrombinaemia. Brit. J. Haemat. 5: 294 1959;
    CrossrefPubMedGoogle Scholar
  • 2 Caen J, Yanotti S, Varangot J, Bernard J. Étude d’un cas d’hypoproconvertinémie vraie congénitale. Sang 30: 535 1959;
    PubMedGoogle Scholar
  • 3 Esch B. van der. Coagulation studies in patients receiving excessively large amounts of vitamin K antagonists. Thesis, Leiden 1966
    PubMed
  • 4 Fantl P. Repair of cardale defect in a patient with Ehlers-Danlos syndrome and deficiency of Hageman Factor. Brit. med. J. I: 1202 1961;
    PubMedGoogle Scholar
  • 5 Goolden A. W. G, Gartside J. M, Szur L. Changes in interstitial fluid in polycythaemia vera. Clin. Sci. 25: 441 1962;
    PubMedGoogle Scholar
  • 6 Hammond J. D. S, Verel D. Observations on the distribution and biological half life of human fibrinogen. Brit. J. Haemat. 5: 431 1959;
    CrossrefPubMedGoogle Scholar
  • 7 Hardisty R. M, Macpherson J. C. A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma. Thrombos. Diathes. haemorrh. (Stuttg.) 7: 215 1962;
    PubMedGoogle Scholar
  • 8 Hensen A, Loeliger E. A. Antithrombin III, its metabolism and its function in blood coagulation. Thrombos. Diathes. haemorrh. (Stuttg.) Suppl. 10 1963
    PubMed
  • 9 Ingram G. I. C, Pinniger J. L, Vallet L. Survival in a afibrinogenaemic subject of fibrinogen prepared from “time-expired” blood. Lancet I: 135 1960;
    PubMedGoogle Scholar
  • 10 Larrieu M. J, Soulier J. P, Culot Y. Déficit en facteur Hageman. Sang 28: 152 1957;
    PubMedGoogle Scholar
  • 11 Loeliger E. A, Hensen A. Substitution therapy in haemophilia B. Thrombos. Diathes. haemorrh. (Stuttg.) 6: 391 1961;
    PubMedGoogle Scholar
  • 12 Loeliger E. A, Veltkamp J. J, Mattern M. J, Hooij H. J. Disposable plastic cuvettes for thrombelastography. Thrombos. Diathes. haemorrh. (Stuttg.) 9: 519 1963;
    PubMedGoogle Scholar
  • 13 Loeliger E. A, van der Esch B, Hemker H. C, Mattem M. J. The biological disappearance rate of prothrombin, factor VII, IX, and X from plasma in hypothyroidism, hyperthyroidism, and during fever. Thrombos. Diathes. haemorrh. (Stuttg.) 10: 267 1964;
    PubMedGoogle Scholar
  • 14 Loeliger E. A, Hensen A, Veltkamp J. J, van der Meer J, Hemker H. C. On the metabolism of factor IX.. Internat. Symp. on Haemophilia, Washington 1963. The University of N. Carolina Press; Chapel Hill, U.S.A.: 1964
    Google Scholar
  • 15 Loeliger E. A, Mattem M. J, Hemker H. C. Transfusion of coumarin induced hypopro-thrombinaemic plasma into a patient suffering from severe congenital hypoprothrombinaemia. Thrombos. Diathes. haemorrh. (Stuttg.) In preparation
    PubMed
  • 16 Ramot B, Singer K, Heller P, Zimmerman H. J. Hageman factor (HF) deficiency. Blood 11: 745 1956;
    PubMedGoogle Scholar
  • 17 Ratnoff O. D, Colopy J. E. A familial haemorrhagic trait associated with a deficiency of a clot promoting fraction of plasma. J. clin. Invest. 34: 602 1955;
    CrossrefPubMedGoogle Scholar
  • 18 Schnitger H. Entwicklung eines neuartigen Gerätes zur automatischen Registrierung von Blutgerinnungszeiten und kritischer Beitrag zur Theorie anderer Meβprinzipien für gerinnungsphysiologische Untersuchungen. Thesis, Marburg 1956
    PubMed
  • 19 Veitkamp J. J. The detection of the carrier state in hereditary coagulation disorders. Thesis, Leiden 1966
    PubMed