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J Reconstr Microsurg
DOI: 10.1055/s-0044-1788565
Original Article

Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats

Tsz Yin Voravitvet 
1   Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan
2   Department of Surgery, Lerdsin Hospital and College of Medicine, Rangsit University, Bangkok, Thailand
,
Yenlin Huang
3   School of Medicine, National Tsing-Hua University, Hsinchu, Taiwan
4   Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
5   Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
,
Sawarin Voravitvet
6   Department of Orthopedic Surgery, Faculty of Medicine, Mahidol University, Siriraj Hospital, Bangkok, Thailand
,
Juan Larsson
7   Department of Plastic and Reconstructive Surgery, Sanatorio Allende, Córdoba, Argentina
8   Department of Trauma and orthopedic Surgery, Sanatorio Allende, Córdoba, Argentina
,
Po-Hao Lien
1   Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan
,
David Chwei-Chin Chuang 
1   Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan
,
Johnny Chuieng-Yi Lu
1   Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan
,
Tommy Nai-Jen Chang
1   Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan
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Abstract

Background One of the most devastating deficits of facial paralysis is eyelid dysfunction, which is controlled by the orbicularis oculi muscle (OOM), as it leads to loss of the protective mechanism of the eye. This study used a rat model to assess the functional outcomes of neurotized platysma muscle grafts (PMGs) for OOM replacement.

Methods Forty male Sprague-Dawley rats with iatrogenic right eyelid dysfunction were divided into five groups: one control group and four groups utilizing PMG with different sources of nerve innervation. Eyelid function recovery was assessed at 2, 4, 6, and 8 weeks. The PMGs were harvested for pathological examination at the end of the study.

Results All rats except those in the control group and one from the group using ipsilateral frontal and upper zygomatic frontal nerve branches directly neurotized to the PMG (nerve-to-muscle) recovered eyelid closure function within 8 weeks of the study period. The mean recovery time was 3.87 ± 1.28 weeks. A total of 87.5% of rats that had the contralateral zygomatic branch as the donor nerve regained the consensual corneal reflex (p-value < 0.001).

Conclusion Replacement of neurotized PMG for OOM function is successful in a rat model. Using the upper zygomatic branch as the donor nerve, it was possible to restore the consensual corneal reflex. This method shows promise for further human studies.

Keywords

facial paralysis - lagophthalmos - eyelid closure


Publication History

Received: 22 March 2024

Accepted: 22 June 2024

Article published online:
22 July 2024

© 2024. Thieme. All rights reserved.

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