Abstract
Interleukin-1 is a potent pro inflammatory agent, has a direct influence on human
thyroid cell function, and modulates cell growth in differentiated thyroid carcinoma
cell lines. To evaluate whether a polymorphism on the IL-1β gene has an influence
on the incidence of thyroid disorders, we analyzed the C + 3954 T polymorphism in
DNA samples of 673 individuals. 414 venous blood samples were collected from patients
suffering from thyroid diseases (Graves' disease n = 53, euthyroid or hyperthyroid
non-immunogenic benign thyroid disorders n = 240, thyroid carcinoma n = 121). 259
persons without thyroid disease served as a control. There was no statistically significant
association between either of the thyroid alterations or functional conditions on
the one hand and the examined genetic polymorphism on the other. Because of the large
number of samples tested we can conclude with a high degree of confidence that there
is no association between the genotype and the surveyed diseases.
Key words
C + 3954 T - polymorphism - thyroid - interleukin-1β
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Ira Reichmann
Department of General and Visceral Surgery
Heinrich-Heine-University
Moorenstraße 5
40225 Düsseldorf
Germany
Telefon: + 49(0)2118117376
Fax: + 49 (0) 21 18 11 50 37
eMail: Ira.Reichmann@uni-duesseldorf.de
