Planta Med 2008; 74(10): 1280-1284
DOI: 10.1055/s-2008-1081291
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Triterpenoid Saponins from Androsace umbellata and their Anti-proliferative Activities in Human Hepatoma Cells

Ying Wang1 , 2 , Dongmei Zhang1 , 2 , Wencai Ye1 , 2 , Zhiqi Yin3 , Kwok-Pui Fung4 , 5 , Shouxue Zhao3 , Xinsheng Yao1 , 2
  • 1Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
  • 2Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangzhou, P. R. China
  • 3Department of Phytochemistry, China Pharmaceutical University, Nanjing, P. R. China
  • 4Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong, P. R. China
  • 5Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, P. R. China
Further Information

Publication History

Received: February 20, 2008 Revised: May 19, 2008

Accepted: May 23, 2008

Publication Date:
11 July 2008 (online)

Abstract

Two new triterpenoid saponins, along with five known ones, were isolated from the EtOH extract of the whole plants of Androsace umbellata. The structures of the new triterpenoid saponins were identified as 3-O-{β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-3β-hydroxy-13β,28-epoxy-16-oxo-oleanan-30-al (1) and 3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-α-L-arabinopyranosyl-3β-hydroxy-13β,28-epoxy-16-oxo-oleanan-30-al (2) on the basis of their spectral and chemical properties. All these compounds showed significant cytotoxic activities in human hepatoma cells.

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Professor Wencai Ye

Institute of Traditional Chinese Medicine and Natural Products

College of Pharmacy

Jinan University

Guangzhou 510632

People’s Republic of China

Phone: +86/20/8522/8369

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