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DOI: 10.1055/a-0668-5746
Contrast-Enhanced Ultrasound of Benign Focal Liver Lesions
Kontrastmittelsonografie benigner LebertumorenPublication History
30 January 2018
12 July 2018
Publication Date:
17 October 2018 (online)
Abstract
The diagnostic handling of benign focal liver lesions (FLLs) is a challenge and it is difficult to avoid over- and underdiagnosis. Conventional B-mode ultrasound and contrast-enhanced ultrasound (CEUS) are the first-line imaging methods to detect and characterize FLLs. This CME article discusses the diagnostic workup of benign liver tumors.
Zusammenfassung
Gutartige Lebertumoren stellen eine Herausforderung im Alltag dar, da sie zur Unter- und Überdiagnostik (Fehldiagnostik) führen können. Der konventionelle Ultraschall und die Kontrastmittelsonografie (CEUS) sind in vielen Fällen die erste und auch entscheidende bildgebende Technik zur Detektion und Charakterisierung von Lebertumoren. In dem CME-Artikel werden aktuelle Überlegungen zur kontrastmittelsonografischen Abklärung von benignen Lebertumoren erläutert.
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References
- 1 Claudon M, Dietrich CF, Choi BI. et al. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver--update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med 2013; 34: 11-29
- 2 Claudon M, Dietrich CF, Choi BI. et al. Guidelines and good clinical practice recommendations for Contrast Enhanced Ultrasound (CEUS) in the liver – update 2012: A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 2013; 39: 187-210
- 3 Strobel D, Seitz K, Blank W. et al. Contrast-enhanced ultrasound for the characterization of focal liver lesions--diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med 2008; 29: 499-505
- 4 Brkljacic B, Castellani S, Deane C. et al. Doppler ultrasound of renal vessels. In: Dietrich CF. ed. EFSUMB Course Book on Ultrasound. London: 2012: 716-736
- 5 Bundesministerium für Umwelt N, Bau und Reaktorsicherheit. RICHTLINIE 2013/59/EURATOM DES RATES vom 5. Dezember 2013 zur Festlegung grundlegender Sicherheitsnormen für den Schutz vor den Gefahren einer Exposition gegenüber ionisierender Strahlung und zur Aufhebung der Richtlinien 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom und 2003/122/Euratom. In: Bundesministrium für Umwelt, Naturschutz, Bau und Reaktorsicherheit; 2013 http://www.bmub.bund.de/themen/atomenergie-strahlenschutz/strahlenschutz/rechtsvorschriften-technische-regeln/regelungen-der-eu/
- 6 Kaltenbach TE, Engler P, Kratzer W. et al. Prevalence of benign focal liver lesions: ultrasound investigation of 45319 hospital patients. Abdom Radiol (NY) 2016; 41: 25-32
- 7 Horta G, Lopez M, Dotte A. et al. Benign focal liver lesions detected by computed tomography: Review of 1184 examinations. Rev Med Chil 2015; 143: 197-202
- 8 Dietrich CF, Tana C, Caraiani C. et al. Contrast enhanced ultrasound (CEUS) imaging of solid benign focal liver lesions. Expert Rev Gastroenterol Hepatol 2018; 12: 479-489
- 9 Kratzer W, Akinli AS, Bommer M. et al. Prevalence and risk factors of focal sparing in hepatic steatosis. Ultraschall Med 2010; 31: 37-42
- 10 Hirche TO, Ignee A, Hirche H. et al. Evaluation of hepatic steatosis by ultrasound in patients with chronic hepatitis C virus infection. Liver Int 2007; 27: 748-757
- 11 Schreiber-Dietrich DG, Leuschner I, Tannapfel A. et al. Primary liver tumours in childhood. Z Gastroenterol 2015; 53: 1267-1275
- 12 Dietrich CF, Schall H, Kirchner J. et al. Sonographic detection of focal changes in the liver hilus in patients receiving corticosteroid therapy. Z Gastroenterol 1997; 35: 1051-1057
- 13 Dietrich CF, Jenssen C. Focal liver lesion, incidental finding. Dtsch Med Wochenschr 2012; 137: 2099-2116
- 14 Dietrich CF, Averkiou M, Nielsen MB. et al. How to perform Contrast-Enhanced Ultrasound (CEUS). Ultrasound Int Open 2018; 4: E2-E15
- 15 Dong Y, Potthoff A, Klinger C. et al. Ultrasound findings in autoimmune hepatitis. World J Gastroenterol 2018; 24: 1583-1590
- 16 Froehlich E, Pauluschke-Froehlich J, Debove I. et al. Geriatric ultrasound. Z Gastroenterol 2017; 55: 277-290
- 17 Dietrich CF, Ignee A, Trojan J. et al. Improved characterisation of histologically proven liver tumours by contrast enhanced ultrasonography during the portal venous and specific late phase of SHU 508A. Gut 2004; 53: 401-405
- 18 Seitz K, Strobel D, Bernatik T. et al. Contrast-Enhanced Ultrasound (CEUS) for the characterization of focal liver lesions – prospective comparison in clinical practice: CEUS vs. CT (DEGUM multicenter trial). Parts of this manuscript were presented at the Ultrasound Dreilandertreffen 2008, Davos. Ultraschall Med 2009; 30: 383-389
- 19 Guang Y, Xie L, Ding H. et al. Diagnosis value of focal liver lesions with SonoVue(R)-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis. J Cancer Res Clin Oncol 2011; 137: 1595-1605
- 20 Xie L, Guang Y, Ding H. et al. Diagnostic value of contrast-enhanced ultrasound, computed tomography and magnetic resonance imaging for focal liver lesions: a meta-analysis. Ultrasound Med Biol 2011; 37: 854-861
- 21 Dietrich CF, Averkiou MA, Correas JM. et al. An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for quantification of tumour perfusion. Ultraschall Med 2012; 33: 344-351
- 22 Dietrich CF, Sharma M, Gibson RN. et al. Fortuitously discovered liver lesions. World J Gastroenterol 2013; 19: 3173-3188
- 23 Ignee A, Atkinson NS, Schuessler G. et al. Ultrasound contrast agents. Endosc Ultrasound 2016; 5: 355-362
- 24 Szebeni J. Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals. Mol Immunol 2014; 61: 163-173
- 25 Szebeni J, Muggia F, Gabizon A. et al. Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention. Adv Drug Deliv Rev 2011; 63: 1020-1030
- 26 Kim TK, Noh SY, Wilson SR. et al. Contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) 2017 – a review of important differences compared to the CT/MRI system. Clin Mol Hepatol 2017; 23: 280-289
- 27 Wilson SR, Lyshchik A, Piscaglia F. et al. CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI. Abdom Radiol (NY) 2017; 43: 127-142
- 28 Piscaglia F, Wilson SR, Lyshchik A. et al. American College of Radiology Contrast Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) for the diagnosis of Hepatocellular Carcinoma: a pictorial essay. Ultraschall Med 2017; 38: 320-324
- 29 Mork H, Ignee A, Schuessler G. et al. Analysis of neuroendocrine tumour metastases in the liver using contrast enhanced ultrasonography. Scand J Gastroenterol 2007; 42: 652-662
- 30 Ignee A, Weiper D, Schuessler G. et al. Sonographic characterisation of hepatocellular carcinoma at time of diagnosis. Z Gastroenterol 2005; 43: 289-294
- 31 Brancatelli G, Federle MP, Blachar A. et al. Hemangioma in the cirrhotic liver: diagnosis and natural history. Radiology 2001; 219: 69-74
- 32 Galia M, Taibbi A, Marin D. et al. Focal lesions in cirrhotic liver: what else beyond hepatocellular carcinoma?. Diagn Interv Radiol 2014; 20: 222-228
- 33 Dietrich CF, Mertens JC, Braden B. et al. Contrast-enhanced ultrasound of histologically proven liver hemangiomas. Hepatology 2007; 45: 1139-1145
- 34 Dong Y, Wang WP, Cantisani V. et al. Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma. World J Gastroenterol 2016; 22: 4741-4749
- 35 Dietrich CF, Schuessler G, Trojan J. et al. Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound. Br J Radiol 2005; 78: 704-707
- 35b Dietrich CF, Tannapfel A, Jang HJ. et al. Ultrasound imaging of hepatocellular adenoma unsing the new histology classification. Ultrasound Med Biol 2018
- 36 Dietrich CF, Lorentzen T, Appelbaum L. et al. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III – Abdominal Treatment Procedures (Long Version). Ultraschall Med 2016; 37: E1-E32
- 37 Ignee A, Jenssen C, Cui XW. et al. Intracavitary contrast-enhanced ultrasound in abscess drainage--feasibility and clinical value. Scand J Gastroenterol 2016; 51: 41-47
- 38 Sidhu PS, Brabrand K, Cantisani V. et al. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part II. Diagnostic Ultrasound-Guided Interventional Procedures (Short Version). Ultraschall Med 2015; 36: 566-580
- 39 Dietrich CF, Kabaalioglu A, Brunetti E. et al. Fasciolosis. Z Gastroenterol 2015; 53: 285-290
- 40 Dietrich CF, Sharma M, Chaubal N. et al. Ascariasis imaging: pictorial essay. Z Gastroenterol 2017; 55: 479-489
- 41 Dong Y, Wang WP, Mao F. et al. Contrast enhanced ultrasound features of hepatic cystadenoma and hepatic cystadenocarcinoma. Scand J Gastroenterol 2017; 52: 365-372
- 42 Hirche TO, Hirche H, Cui XW. et al. Ultrasound evaluation of mediastinal lymphadenopathy in patients with sarcoidosis. Med Ultrason 2014; 16: 194-200
- 43 Dietrich CF, Greis C. How to perform contrast enhanced ultrasound. Dtsch Med Wochenschr 2016; 141: 1019-1024
- 44 Cui XW, Ignee A, Hocke M. et al. Prolonged heterogeneous liver enhancement on contrast-enhanced ultrasound. Ultraschall Med 2014; 35: 246-252
- 45 Schuessler G, Fellbaum C, Fauth F. et al. The infammatory pseudotumour – an unusual liver tumour. Ultraschall Med 2006; 27: 273-279