The analysis of the study entitled “Exercise Interventions and Cardiovascular
Health in Childhood Cancer: a Meta-Analysis” [1] was very interesting. The authors of this meta-analysis aimed to
summarize the evidence on the effects of physical training intervention over three
weeks on cardiovascular and cardiorespiratory outcomes in childhood cancer survivors
(CCS). In addition, they addressed endpoints related not only to cardiac structure
and function, but also to cardiorespiratory fitness.
1
Morales JS,
Valenzuela PL,
Herrera-Olivares AM.
et al. Exercise interventions and cardiovascular health in childhood cancer: A
meta-analysis. Int J Sports Med 2020; 41: 141-153
2
Hamo CE,
Bloom MW.
Getting to the heart of the matter: An overview of cardiac toxicity related to
cancer therapy. Clin Med Insights Cardiol 2015; 9 (Suppl 2): 47-51
5
Strongman H,
Gadd S,
Matthews A.
et al. Medium and long-term risks of specific cardiovascular diseases in survivors of
20 adult cancers: A population-based cohort study using multiple linked UK
electronic health records databases. Lancet 2019; 394: 1041-1054
6
Wenningmann N,
Knapp M,
Ande A.
et al. Insights into Doxorubicin-induced Cardiotoxicity: Molecular mechanisms,
preventive strategies, and early monitoring. Mol Pharmacol 2019; 96: 219-232
7
Duncan M,
Moschopoulou E,
Herrington E.
et al. Review of systematic reviews of non-pharmacological interventions to improve
quality of life in cancer survivors. BMJ Open 2017; 7: e015860
8
Thijssen DHJ,
Redington A,
George KP.
et al. Association of exercise preconditioning with immediate cardioprotection: A
review. JAMA cardiology 2018; 3: 169-176
9
Mandsager K,
Harb S,
Cremer P.
et al. Association of cardiorespiratory fitness with long-term mortality among adults
undergoing exercise treadmill testing. JAMA Network Open 2018; 1: e183605
11
Campbell KL.
et al. Exercise Guidelines for Cancer Survivors: Consensus Statement from International
Multidisciplinary Roundtable. Med Sci Sports Exerc 2019; 51: 2375-2390
12
Patel AV.
et al. American College of Sports Medicine Roundtable Report on Physical Activity,
Sedentary Behavior, and Cancer Prevention and Control. Med Sci Sports Exerc 2019; 51: 2391-2402
13
Sweegers MG.
et al. Which exercise prescriptions improve quality of life and physical function in
patients with cancer during and following treatment? A systematic review and
meta-analysis of randomised controlled trials. Br J Sports Med 2018; 52: 505-513