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Synthesis 2022; 54(02): 475-482
DOI: 10.1055/a-1645-6040
DOI: 10.1055/a-1645-6040
paper
Synthesis of Aryl Dithiocarbamates from Tetramethylthiuram Monosulfide (TMTM) and Aryl Boronic Acids: Copper-Catalyzed Construction of C(sp2)–S Bonds
Financial support from the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University (2020ZD02), the Key Laboratory of Organosilicon Chemistry and Material Technology of the Ministry of Education, Hangzhou Normal University (KFJJ2021008), and Hubei Key Laboratory of Biologic Resources Protection and Utilization, Hubei Minzu University (PT012101) is greatly appreciated. X.-L. X and Q.-L. Z. are grateful for support by the Principal’s Fund from the Wuhan Institute of Technology (2020116).
Abstract
A highly efficient method for the synthesis of S-aryl dithiocarbamates is reported. By using tetramethylthiuram monosulfide (TMTM) and aryl boronic acids as starting materials, C(sp2)–S bond-forming reactions proceed smoothly to give the desired aryl dithiocarbamates in good to excellent yields. The methodology features a simple procedure, broad functional group tolerance and excellent yields, whilst showing potential synthetic value for the preparation of a diverse range of biologically and pharmaceutically active compounds.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1645-6040.
- Supporting Information
Publication History
Received: 12 August 2021
Accepted after revision: 15 September 2021
Accepted Manuscript online:
15 September 2021
Article published online:
14 October 2021
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